Department of Internal Medicine, Diabetes Unit, State University of Rio de Janeiro, Rio de Janeiro, Brazil.
Diabetes Outpatient Clinic, Pediatric Endocrine Unit, Santa Casa School of Medical Sciences, São Paulo, Brazil.
Pediatr Diabetes. 2020 Aug;21(5):727-734. doi: 10.1111/pedi.13031. Epub 2020 May 7.
To determine the influence of genomic ancestry (GA) and self-reportedcolor-race (SRCR) on glycemic control in adolescents with type 1 diabetes (T1D) in an admixed population.
This multicenter nationwide study was conducted in 14 public clinics in 10 Brazilian cities. We estimated global and individual African, European, and Native Amerindian GA proportions using a panel of 46 AIM-INDEL markers. From 1760 patients, 367 were adolescents (20.9%): 184 female (50.1%), aged 16.4 ± 1.9 years, age at diagnosis 8.9 ± 4.3 years, duration of diabetes 8.1 ± 4.3 years, years of study 10.9 ± 2.5 and HbA1c of 9.6 ± 2.4%.
Patients SRCR as White: 176 (48.0%), Brown: 159 (43.3%), Black: 19(5.2%), Asians: 5 (1.4%) and Amerindians: 8 (2.2%). The percentage of European GA prevailed in all groups: White (71.1), Brown (58.8), Black (49.6), Amerindians (46.1), and Asians (60.5). Univariate correlation was noted between A1c and African GA, r = 0.11, P = .03; years of study, r = -0.12 P = .010, and having both private and public health care insurance (r = -0.20, P < .001). After adjustments, the multivariate logistic analysis showed that SRCR or GA did not influence glycemic control.
A high percentage of European GA was noted in our patients, even in those who self-reported as non-White, confirming the highly admixed ethnicity of the Brazilian population. Better glycemic control was associated with having both types of health care; however, there was no association between glycemic control with GA or SRCR. Future prospective studies with other admixed populations are necessary to confirm our findings.
在一个混合人群中，确定基因组血统（GA）和自我报告的肤色种族（SRCR）对 1 型糖尿病（T1D）青少年血糖控制的影响。
这项多中心全国性研究在巴西 10 个城市的 14 个公共诊所进行。我们使用 46 个 AIM-INDEL 标记的面板来估计全球和个体的非洲、欧洲和美洲原住民 GA 比例。在 1760 名患者中，有 367 名是青少年（20.9%）：184 名女性（50.1%），年龄 16.4±1.9 岁，诊断年龄 8.9±4.3 岁，糖尿病病程 8.1±4.3 年，研究年限 10.9±2.5 年，HbA1c 为 9.6±2.4%。
患者的 SRCR 为白人：176 人（48.0%），棕色人种：159 人（43.3%），黑人：19 人（5.2%），亚洲人：5 人（1.4%）和美洲原住民：8 人（2.2%）。所有组中欧洲 GA 的比例均占主导地位：白人（71.1%），棕色人种（58.8%），黑人（49.6%），美洲原住民（46.1%）和亚洲人（60.5%）。单变量相关性分析显示 A1c 与非洲 GA 呈正相关，r = 0.11，P =.03；与研究年限呈负相关，r = -0.12，P = .010，与同时拥有私人和公共医疗保险呈负相关（r = -0.20，P < .001）。经过调整，多变量逻辑分析表明，SRCR 或 GA 并不影响血糖控制。
我们的患者中欧洲 GA 的比例很高，即使是自我报告为非白人的患者也是如此，这证实了巴西人口的高度混合种族。更好的血糖控制与同时拥有两种类型的医疗保健有关；然而，血糖控制与 GA 或 SRCR 之间没有关联。未来需要对其他混合人群进行前瞻性研究，以证实我们的发现。
