硫酸羟氯喹导致结缔组织病患者低血糖，该患者无糖尿病。
Hypoglycemia Induced by Hydroxychloroquine Sulfate in a Patient Treated for Connective Tissue Disease Without Diabetes Mellitus.
机构信息
Department of Pharmacy, First Affiliated Hospital of Wenzhou Medical University, Wenzhou City, China.
Department of Pharmacy, First Affiliated Hospital of Wenzhou Medical University, Wenzhou City, China.
出版信息
Clin Ther. 2020 May;42(5):940-945. doi: 10.1016/j.clinthera.2020.03.011. Epub 2020 Apr 23.
PURPOSE
Several case reports have highlighted symptomatic hypoglycemia as a serious but uncommon adverse effect of hydroxychloroquine (HCQ) in nondiabetic subjects.
METHODS
This study describes a nondiabetic patient who experienced serious hypoglycemia related to HCQ.
FINDINGS
In the course of treatment, the patient experienced multiple episodes of hypoglycemia at night and in the early morning. The hypoglycemia was usually accompanied by nausea, fatigue, and dizziness. The lowest value of blood glucose in the fingertip was 2.6 mmol/L.
IMPLICATIONS
This rare case will prompt clinicians to pay attention to unexplained hypoglycemia when using HCQ in nondiabetic patients.
目的
已有数份病例报告强调，羟氯喹（HCQ）在非糖尿病患者中可引起症状性低血糖，虽然较为少见但后果严重。
方法
本研究介绍了一例非糖尿病患者因使用 HCQ 而出现严重低血糖的病例。
发现
在治疗过程中，该患者夜间和清晨多次发生低血糖，低血糖通常伴有恶心、乏力和头晕。指尖血糖最低值为 2.6mmol/L。
启示
该罕见病例提示临床医生在非糖尿病患者使用 HCQ 时应注意不明原因的低血糖。
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