Pathak Abhishek, Nath Chaurasia Rameshwar, Kumar Singh Varun, Shukla Upasana, Joshi Deepika, Nath Mishra Vijaya
Department of Neurology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, India.
Department of Neurology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, India.
J Clin Neurosci. 2020 Aug;78:139-142. doi: 10.1016/j.jocn.2020.04.096. Epub 2020 Apr 23.
Cerebral Venous Thrombosis (CVT) is a well-known disease with diverse clinical presentation and causes. With advances in neuroimaging and changing lifestyles, the clinical profile and causes of CVT are changing. D-dimer has been studied in early diagnosis of CVT with variable results. This prospective study was carried out to assess the clinical profile of CVT and role of D-dimer in early diagnosis of CVT. The study period was from September 2017 to July 2019 and included 32 imaging proven patients of CVT. We also included 32 patients of migraine for assessing D-dimer. Data was collected according to a preformed format. D-dimer was assessed by a rapid semi-quantitative latex agglutination assay. Out of 32 CVT patients, 16(50%) were females. The mean age of the patients was 31.56 ± 14.31 years. Most common clinical features were headache (96.25%), papilloedema (37.5%) and seizures 10 (31.25%). Puerperium was the most common cause of CVT in females. Superior sagittal and transverse sinuses were the most common sinuses to be affected. The sensitivity of D-dimer assay was 81.25% and specificity 62.5%. Cerebral venous thrombosis is a disease with equal predilection among both genders affecting mostly young individuals. Most of the patients present with headache. Puerperium still contributes to majority of the cases. Iron deficiency anaemia needs to be evaluated as an association for CVT. Positive D-dimer should strengthen the suspicion of CVT in patients with acute headache.
脑静脉血栓形成（CVT）是一种临床表现多样、病因各异的常见疾病。随着神经影像学的发展和生活方式的改变，CVT的临床特征和病因也在发生变化。D-二聚体已被用于CVT的早期诊断研究，但结果不一。本前瞻性研究旨在评估CVT的临床特征以及D-二聚体在CVT早期诊断中的作用。研究时间为2017年9月至2019年7月，纳入32例经影像学证实的CVT患者。我们还纳入了32例偏头痛患者以评估D-二聚体。数据按照预先制定的格式收集。D-二聚体通过快速半定量乳胶凝集试验进行评估。32例CVT患者中，16例（50%）为女性。患者的平均年龄为31.56±14.31岁。最常见的临床特征是头痛（96.25%）、视乳头水肿（37.5%）和癫痫发作10例（31.25%）。产褥期是女性CVT最常见的病因。上矢状窦和横窦是最常受累的静脉窦。D-二聚体检测的敏感性为81.25%，特异性为62.5%。脑静脉血栓形成是一种男女发病率相当、主要影响年轻人的疾病。大多数患者表现为头痛。产褥期仍是大多数病例的病因。缺铁性贫血作为CVT的关联因素需要进行评估。D-二聚体阳性应增加对急性头痛患者CVT的怀疑。
