Department of Food Science and Technology, Seoul National University of Science and Technology, Seoul 01811, Korea.
Department of Nutritional Science and Food Management, Ewha Womans University, Seoul 03760, Korea.
Molecules. 2020 Apr 23;25(8):1967. doi: 10.3390/molecules25081967.
Red ginseng has been widely used in health-promoting supplements in Asia and is becoming increasingly popular in Western countries. However, its therapeutic mechanisms against most diseases have not been clearly elucidated. The aim of the present study was to provide the biological mechanisms of red ginseng against various metabolic diseases. We used a systems biological approach to comprehensively identify the component-target and target-pathway networks in order to explore the mechanisms underlying the therapeutic potential of red ginseng against metabolic diseases. Of the 23 components of red ginseng with target, 5 components were linked with 37 target molecules. Systematic analysis of the constructed networks revealed that these 37 targets were mainly involved in 9 signaling pathways relating to immune cell differentiation and vascular health. These results successfully explained the mechanisms underlying the efficiency of red ginseng for metabolic diseases, such as menopausal symptoms in women, blood circulation, diabetes mellitus, and hyperlipidemia.
红参在亚洲被广泛用于促进健康的补品，在西方国家也越来越受欢迎。然而，它对大多数疾病的治疗机制尚未得到明确阐明。本研究的目的是提供红参对抗各种代谢性疾病的生物学机制。我们使用系统生物学方法全面识别成分-靶标和靶标-通路网络，以探索红参治疗代谢性疾病的潜在机制。在具有靶标的红参的 23 个成分中，有 5 个成分与 37 个靶分子相连。对构建网络的系统分析表明，这 37 个靶点主要涉及与免疫细胞分化和血管健康相关的 9 个信号通路。这些结果成功解释了红参治疗代谢性疾病（如女性更年期症状、血液循环、糖尿病和高脂血症）的机制。
