Department of Otolaryngology-Head and Neck Surgery, Tulane University, New Orleans, Louisiana, USA.
Ochsner Health System, Center for Outcomes and Health Services Research, New Orleans, Louisiana, USA.
Otolaryngol Head Neck Surg. 2020 Sep;163(3):560-562. doi: 10.1177/0194599820917669. Epub 2020 Apr 28.
Gastroesophageal reflux disease (GERD) has been hypothesized as a risk factor for development of laryngeal cancer. A case-control study was performed to assess the association of laryngeal neoplasia with GERD. Cases consisted of patients with a history of laryngeal cancer or carcinoma in situ. Controls were patients without neoplasia who matched cases 2:1 on age, sex, race, and smoking history. Univariate and multivariate analyses were performed to assess risk of laryngeal neoplasia and GERD. In total, 2094 patients were included. Cases had higher rates of GERD. Univariate analysis demonstrated a positive association between GERD and laryngeal neoplasia (odds ratio, 1.33; 95% CI, 1.07-1.64). Multivariate analysis controlling for alcohol use history also demonstrated a positive association between GERD and laryngeal neoplasia (adjusted odds ratio, 1.29; 95% CI, 1.04-1.59). These results suggest increased odds of laryngeal carcinoma and carcinoma in situ in patients with GERD when controlling for smoking and drinking history.
胃食管反流病（GERD）被认为是喉癌发展的危险因素。进行了一项病例对照研究，以评估 GERD 与喉肿瘤之间的关联。病例组由有喉癌或原位癌病史的患者组成。对照组为无肿瘤的患者，其年龄、性别、种族和吸烟史与病例组匹配 2:1。进行单变量和多变量分析以评估喉肿瘤和 GERD 的风险。共有 2094 名患者纳入研究。病例组 GERD 发生率更高。单变量分析显示 GERD 与喉肿瘤之间存在正相关（比值比，1.33；95%置信区间，1.07-1.64）。控制饮酒史的多变量分析也显示 GERD 与喉肿瘤之间存在正相关（调整比值比，1.29；95%置信区间，1.04-1.59）。这些结果表明，在控制吸烟和饮酒史后，GERD 患者患喉癌和原位癌的几率增加。
