Department of Rheumatology, Saint-Joseph University, Hôtel-Dieu de France Hospital, BP 166830, Achrafieh, Beirut, Lebanon.
Division of Rheumatology, Department of Precision Medicine, University of Campania "Luigi Vanvitelli", Via Sergio Pansini 5, Napoli 80131, Italy.
Rheum Dis Clin North Am. 2020 May;46(2):225-239. doi: 10.1016/j.rdc.2020.01.002.
Human leukocyte antigen (HLA) B27 is the key laboratory parameter for axial spondyloarthritis (axSpA). Its prevalence is variable across different geographic zones and ethnicities, and often mirrors the prevalence of axSpA. HLA-B27 plays a role in axSpA physiopathology. It is correlated with spondyloarthritis phenotype with a consistent positive association with family history, early disease onset, shorter diagnostic delay, hip involvement, and acute anterior uveitis. HLA-B27 has a pivotal role in many referral strategies. However, these strategies were developed in European populations and need to be evaluated in populations with lower HLA-B27 background prevalence, and where additional parameters might be needed.
人类白细胞抗原（HLA）B27 是中轴型脊柱关节炎（axSpA）的关键实验室参数。其在不同地理区域和种族中的流行率存在差异，通常与 axSpA 的流行率一致。HLA-B27 在 axSpA 的病理生理学中起作用。它与脊柱关节炎表型相关，与家族史、疾病早期发作、较短的诊断延迟、髋关节受累和急性前葡萄膜炎呈一致的正相关。HLA-B27 在许多转诊策略中起着关键作用。然而，这些策略是在欧洲人群中制定的，需要在 HLA-B27 背景流行率较低的人群中进行评估，并且可能需要其他参数。
