Woroch Brion, Konkel Alex, Gonsalves Brian D
Department of Psychology, University of Illinois, Champaign, IL, USA.
Beckman Institute for Advanced Science and Technology, Urbana, IL, USA.
AIMS Neurosci. 2019 Oct 17;6(4):250-265. doi: 10.3934/Neuroscience.2019.4.250. eCollection 2019.
Many theories of episodic memory posit that the subjective experience of recollection may be driven by the activation of stimulus-specific cortical regions during memory retrieval. This study examined cortical activation during associative memory retrieval to identify brain regions that support confidence judgments of source memory in stimulus-specific ways. Adjectives were encoded with either a picture of a face or a scene. During a source memory test, the word was presented alone and the participant was asked if the word had been previously paired with a face or a scene. We identified brain regions that were selectively active when viewing pictures of scenes or faces with a separate localizer scan. We then identified brain regions that were differentially activated to words during the source memory test that had been previously paired with faces or scenes, masked by the localizer activations, and examined how those regions were modulated by the strength of the source memory. Bilateral amygdala activation tracked source memory confidence for faces, while parahippocampal cortex tracked source memory confidence for scenes. The magnitude of the activation of these domain-specific perceptual-processing brain regions during memory retrieval may contribute to the subjective strength of episodic recollection.
许多情景记忆理论认为，回忆的主观体验可能是由记忆检索过程中特定刺激皮层区域的激活所驱动的。本研究考察了联想记忆检索过程中的皮层激活情况，以确定以特定刺激方式支持源记忆信心判断的脑区。形容词与面部图片或场景图片一起进行编码。在源记忆测试中，单独呈现单词，并询问参与者该单词之前是与面部还是场景配对。我们通过单独的定位扫描确定了在观看场景或面部图片时选择性活跃的脑区。然后，我们确定了在源记忆测试期间，那些之前与面部或场景配对的单词在定位器激活的掩盖下有差异激活的脑区，并研究了这些区域如何受到源记忆强度的调节。双侧杏仁核激活跟踪对面部的源记忆信心，而海马旁皮层跟踪对场景的源记忆信心。在记忆检索过程中，这些特定领域的感知处理脑区激活的程度可能有助于情景回忆的主观强度。
