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ASO Author Reflections: Pancreatic Cancer Patients with Germline BRCA Mutations Benefit from Early Introduction of Platinum-Based Chemotherapy.

作者信息

Golan Talia, Barenboim Alex, Lubezky Nir

机构信息

Institute of Oncology, Sheba Medical Center, Tel Hashomer, Israel.

Sackler Faculty of Medicine, Tel-Aviv University, Tel Aviv, Israel.

出版信息

Ann Surg Oncol. 2020 Oct;27(10):3971-3972. doi: 10.1245/s10434-020-08495-6. Epub 2020 Apr 27.

DOI:10.1245/s10434-020-08495-6
PMID:32342298
Abstract
摘要

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Should platinum-based chemotherapy be preferred for germline BReast CAncer genes (BRCA) 1 and 2-mutated pancreatic ductal adenocarcinoma (PDAC) patients? A systematic review and meta-analysis.对于胚系 BRCA 基因 1 和 2 突变的胰腺导管腺癌(PDAC)患者,是否应优先选择基于铂类的化疗?系统评价和荟萃分析。
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BRCA1 and BRCA2 mutations sensitize to chemotherapy in patient-derived pancreatic cancer xenografts.BRCA1和BRCA2突变使源自患者的胰腺癌异种移植瘤对化疗敏感。
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An emerging entity: pancreatic adenocarcinoma associated with a known BRCA mutation: clinical descriptors, treatment implications, and future directions.一种新兴实体:与已知 BRCA 突变相关的胰腺腺癌:临床特征、治疗意义和未来方向。
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Chemotherapy and radiotherapy for advanced pancreatic cancer.晚期胰腺癌的化疗与放疗
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