School of Chemistry and Chemical Engineering, Shandong University, Jinan, 250100, China.
The Key Laboratory of Special Functional Aggregated Materials, Ministry of Education, Shandong University, Jinan, 250100, China.
Chemistry. 2020 Aug 3;26(43):9445-9448. doi: 10.1002/chem.202001959. Epub 2020 Jul 20.
Current drug delivery systems gain more functions with increased complexity. With the idea of less is more, we synthesized hexanoate-cucurbit[7]uril (CB[7]C COONa) with multiple promising features for drug delivery. The hexanoate group integrates multiple functions. It endows CB[7]C COONa extremely high solubility of over 600 mg mL and well-defined pH-controlled release ability without sacrificing on the high binding affinity of CB[7] cavity. Based on the pH-controlled release ability, CB[7]C COONa can be used for controlling the bioactivity of drug molecules. We anticipate that the strategy of function integration would be useful for the design of simple yet powerful drug delivery systems.
目前的药物传递系统通过增加复杂性获得了更多的功能。受“少即是多”理念的启发，我们合成了具有多种药物传递功能的己酸-葫芦[7]脲（CB[7]C COONa）。己酸基团集成了多种功能。它使 CB[7]C COONa 的溶解度超过 600mg/mL，具有明确的 pH 控制释放能力，同时不牺牲 CB[7]空腔的高结合亲和力。基于 pH 控制释放能力，CB[7]C COONa 可用于控制药物分子的生物活性。我们预计，这种功能集成策略对于设计简单而强大的药物传递系统将是有用的。
