Shandong Institute of Parasitic Diseases, Shandong First Medical University & Shandong Academy of Medical Sciences, Jining, Shandong Province, China.
Shandong Institute of Parasitic Diseases, Shandong First Medical University & Shandong Academy of Medical Sciences, Jining, Shandong Province, China.
Int J Infect Dis. 2020 Jul;96:199-204. doi: 10.1016/j.ijid.2020.04.052. Epub 2020 Apr 25.
The aim of this study was to investigate the epidemic scope, epidemic pattern and degree of damage of clonorchiasis as well as to summarize the diagnosis and control effect of clonorchiasis in Shandong Province, China.
A retrospective study was conducted to summarize the research on the dynamic epidemiology and the prevention and treatment measures of clonorchiasis in Shandong Province, China from 1962 to 2015.
After unremitting efforts and three nationwide surveys on the distribution and infection of human parasites, the infection rate of clonorchiasis decreased from 1.51% (1,500, 000) in the1960s to 0.16% in 1991, 0.04% in 2000 and 0.007% in 2015, respectively. The infection rate for villages with perennial water accumulation and rainy season water accumulation was higher than that of villages with rainy season water accumulation and non-water accumulation. The egg flotation in 70% potassium iodide solution method was applied to accurately test the specific proportion of C. sinensis eggs, which was 1.42. Using the modified Kato thick smear method, the detection rate of eggs was over 98%; hexachloroparaxylene yielded satisfactory therapeutic effects with slight adverse reactions, it is effective in the treatment of clonorchiasis.
After 50 years of active prevention and treatment, the disease has been successfully controlled in Shandong Province and had been used for reference in other endemic areas of clonorchiasis in China.
本研究旨在调查华支睾吸虫病的流行范围、流行模式和危害程度，并总结山东省华支睾吸虫病的诊断和防治效果。
采用回顾性研究方法，总结 1962 年至 2015 年山东省华支睾吸虫病动态流行病学及防治措施的研究。
经过不懈努力和三次全国人体寄生虫分布及感染情况调查，华支睾吸虫病感染率从 20 世纪 60 年代的 1.51%（150 万）下降至 1991 年的 0.16%、2000 年的 0.04%和 2015 年的 0.007%。常年积水和雨季积水村的感染率高于雨季积水和非积水村。70%碘化钾溶液虫卵漂浮法准确检测华支睾吸虫卵的具体比例，为 1.42。采用改良加藤厚涂片法，虫卵检出率超过 98%；六氯对二甲苯疗效满意，不良反应轻微，对治疗华支睾吸虫病有效。
经过 50 年的积极防治，山东省已成功控制了该病，并为中国其他华支睾吸虫病流行地区提供了借鉴。
