Alexopoulos D, Horowitz S F, Ambrose J A, Machac J
Department of Medicine, Mount Sinai Medical Centre, New York, NY 10029.
Eur Heart J. 1988 Nov;9(11):1223-9. doi: 10.1093/oxfordjournals.eurheartj.a062433.
Relative changes in pulmonary blood volume (PBV) were assessed serially at first stage, peak and post-supine exercise in 13 young normal volunteers and 33 coronary artery disease (CAD) patients. Gated blood pool imaging was used with time corrected count calculation of a region over the lung and comparison to the rest image. In normal subjects, the PBV ratio did not change with exercise but dropped significantly immediately post-exercise. In CAD patients, the PBV ratio increased in the first exercise stage, increased further at peak exercise, and fell significantly following exercise cessation. In the three stages studied, significantly higher PBV ratios were demonstrated in the CAD patients compared to normal subjects, but with significant overlap between the two groups. No significant relation was found between PBV changes and the number of diseased vessels, severity score (Gensini), left ventricular end-diastolic pressure, exercise-limiting symptoms, and left and right ventricular ejection fraction at rest and with exercise. Despite the different response of the PBV ratio to exercise between normals and CAD patients, a significant overlap limits the value of this ratio as a discriminator of the presence, severity or location of CAD.
在13名年轻正常志愿者和33名冠状动脉疾病（CAD）患者中，在第一阶段、运动峰值和仰卧位运动后连续评估肺血容量（PBV）的相对变化。采用门控心血池显像技术，对肺部一个区域进行时间校正计数计算，并与静止图像进行比较。在正常受试者中，PBV比值在运动时没有变化，但在运动后立即显著下降。在CAD患者中，PBV比值在运动第一阶段增加，在运动峰值时进一步增加，并在运动停止后显著下降。在所研究的三个阶段中，CAD患者的PBV比值显著高于正常受试者，但两组之间有显著重叠。未发现PBV变化与病变血管数量、严重程度评分（Gensini）、左心室舒张末期压力、运动受限症状以及静息和运动时左右心室射血分数之间存在显著关系。尽管正常人和CAD患者的PBV比值对运动的反应不同，但显著的重叠限制了该比值作为CAD存在、严重程度或位置鉴别指标的价值。
