Research Center for Behavioral Disorders and Substances Abuse, Hamadan University of Medical Sciences, Hamadan, Iran.
Department of Immunology, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran.
J Neuroimmunol. 2020 Jul 15;344:577250. doi: 10.1016/j.jneuroim.2020.577250. Epub 2020 Apr 23.
The properties of CD4CD25 T regulatory cells (Tregs), and interleukin (IL)-2 pathway were investigated in major depressive disorder (MDD) patients treated with or without selective serotonin reuptake inhibitor (SSRI). The frequencies of FOXP3 and pSTAT5 in peripheral Tregs were found to be diminished in untreated patients (SSRI) versus HCs (p < .001 for both), while their percentages were increased in treated patients (SSRI) versus untreated patients (p < .001 and p = .04). The proliferation of CD4 T cells was higher in SSRIMDD patients versus HCs (p = .03). The SSRIMDD patients showed a lower concentration of supernatant TGF-β than HCs (p = .001), while the production of TGF-β was enhanced in SSRIMDD versus SSRIMDD patients (p = .003). The number of CD45RA-expressing Tregs, the expression of JAK1 and JAK3, and the levels of IL-2 and IL-10 were similar between the patients and HCs. The study results showed that untreated patients have an impaired IL-2 signaling pathway and defective Tregs, and SSRI treatment may improve the Tregs function.
研究了未接受选择性 5-羟色胺再摄取抑制剂（SSRI）治疗和接受 SSRI 治疗的重度抑郁症（MDD）患者中 CD4+CD25+调节性 T 细胞（Tregs）的特性和白细胞介素（IL）-2 通路。与健康对照（HCs）相比，未经治疗的患者（SSRI）外周血 Tregs 中 FOXP3 和 pSTAT5 的频率降低（均为 p<0.001），而经治疗的患者（SSRI）的比例高于未经治疗的患者（均为 p<0.001 和 p=0.04）。与 HCs 相比，SSRI+MDD 患者的 CD4+T 细胞增殖率更高（p=0.03）。与 HCs 相比，SSRI+MDD 患者的上清液 TGF-β浓度较低（p=0.001），而 SSRI+MDD 患者的 TGF-β产生增强（p=0.003）。CD45RA 表达的 Tregs 数量、JAK1 和 JAK3 的表达以及 IL-2 和 IL-10 的水平在患者和 HCs 之间相似。研究结果表明，未经治疗的患者存在 IL-2 信号通路受损和 Tregs 功能缺陷，而 SSRI 治疗可能改善 Tregs 功能。
