Xu Ke, Ahan Ayifuhan
The First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang, China.
The First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang, China.
Med Hypotheses. 2020 Sep;142:109735. doi: 10.1016/j.mehy.2020.109735. Epub 2020 Apr 13.
Recently, it is found that there is high concentration of potassium in tumor interstitial fluid, which causes "T cell exhaustion" and even autophagy of lymphocytes in tumors. The immune mechanism of the late stage of alveolar echinococcosis (AE) is similar to that of tumor immunity. We speculate that the growth and development of the worm body, the necrosis of the worm body and the release of high concentrations of potassium after hepatocyte necrosis in the pathological process of AE may cause "T cell exhaustion" in AE patients. If this assumption can be confirmed experimentally, T cell adoptive transfer around the AE infiltration zone will be utilized to assist the treatment of AE patients with complex conditions.
最近发现肿瘤间质液中钾浓度很高，这会导致肿瘤内“T细胞耗竭”甚至淋巴细胞自噬。肺泡型棘球蚴病（AE）晚期的免疫机制与肿瘤免疫相似。我们推测，在AE的病理过程中，虫体的生长发育、虫体坏死以及肝细胞坏死后释放的高浓度钾可能导致AE患者出现“T细胞耗竭”。如果这一假设能通过实验得到证实，将利用在AE浸润区周围进行T细胞过继转移来辅助治疗病情复杂的AE患者。
