Edwards G, Dingsdale A, Helsby N, Orme M L, Breckenridge A M
Department of Pharmacology and Therapeutics, University of Liverpool, UK.
Eur J Clin Pharmacol. 1988;35(6):681-4. doi: 10.1007/BF00637608.
Administration of 12-mg doses of ivermectin (H2B1a) to 12 healthy volunteers in the form of tablets, capsules, and alcoholic oral solution showed the solution to have approximately twice the systemic availability as either of the solid forms, as evidenced both by the maximum concentrations of drug attained in plasma and by the corresponding areas under the plasma concentration vs time curves. However, the two solid formulations showed similar systemic availability.
以片剂、胶囊和酒精口服溶液形式向12名健康志愿者服用12毫克剂量的伊维菌素（H2B1a），结果显示该溶液的全身可用性约为两种固体形式的两倍，这在血浆中达到的药物最大浓度以及血浆浓度与时间曲线下的相应面积中均得到证实。然而，两种固体剂型显示出相似的全身可用性。
