百日咳毒素可使海马体中的突触前5-羟色胺自身受体失活。
Pertussis toxin inactivates the presynaptic serotonin autoreceptor in the hippocampus.
作者信息
Passarelli F, Costa T, Almeida O F
机构信息
Department of Neuropharmacology, Max-Planck-Institut für Psychiatrie, München, F.R.G.
出版信息
Eur J Pharmacol. 1988 Oct 18;155(3):297-9. doi: 10.1016/0014-2999(88)90517-1.
The serotonin (5-HT) agonists, D-lysergic acid diethylamide (LSD) and 5-methoxytryptamine (5-Me-O-T), dose dependently inhibited the K+-evoked outflow of [3H]5-HT from preloaded rat hippocampal slices in vitro, indicating activation of the 5-HT autoreceptor. However, this effect was abolished in slices pretreated with pertussis toxin. It is thus concluded that the 5-HT autoreceptor in the hippocampus is coupled to G proteins.
血清素（5-羟色胺，5-HT）激动剂，D-麦角酸二乙酰胺（LSD）和5-甲氧基色胺（5-Me-O-T），在体外剂量依赖性地抑制预加载的大鼠海马切片中由钾离子诱发的[3H]5-HT外流，表明5-HT自身受体被激活。然而，在用百日咳毒素预处理的切片中，这种效应被消除。因此得出结论，海马中的5-HT自身受体与G蛋白偶联。
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