一氧化氮从离体豚鼠心脏释放。
Nitric oxide release from the isolated guinea pig heart.
作者信息
Kelm M, Schrader J
机构信息
Institute of Physiology, University of Düsseldorf, F.R.G.
出版信息
Eur J Pharmacol. 1988 Oct 18;155(3):317-21. doi: 10.1016/0014-2999(88)90522-5.
Nitric oxide (NO) release from isolated guinea pig hearts into the coronary effluent perfusate was measured with a specific spectrophotometric assay. Nitric oxide was continuously released under basal conditions at a rate of 216 +/- 36 pmol/min. Bradykinin (5 X 10(-10)-10(-8) M) stimulated the release of nitric oxide in a dose-dependent manner. The start of NO release preceded coronary vasodilation by 5 +/- 1 s. Our results suggest that the endogenous formation of nitric oxide is quantitatively sufficient to influence the coronary vascular tone and thus may play a significant role in the regulation of coronary vascular resistance.
采用特定的分光光度法测定了从离体豚鼠心脏释放到冠状动脉流出灌注液中的一氧化氮（NO）。在基础条件下，一氧化氮以216±36 pmol/分钟的速率持续释放。缓激肽（5×10⁻¹⁰ - 10⁻⁸ M）以剂量依赖的方式刺激一氧化氮的释放。一氧化氮释放开始比冠状动脉血管舒张提前5±1秒。我们的结果表明，内源性一氧化氮的形成在数量上足以影响冠状动脉血管张力，因此可能在冠状动脉血管阻力的调节中起重要作用。
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