Gurkovskaia A V, Gokina N I, Stepaniuk G I
Farmakol Toksikol. 1988 Nov-Dec;51(6):69-72.
The effect of voltaren on the electrical and contractile activity of smooth muscle cells of the rabbit portal vein and the bovine cerebral arteries was studied by sucrose gap method. Voltaren was found to rarefy (10(-6)-10-10(-3)mol/l) or to suppress (10(-4)-10(-3)mol/l) spontaneous electrical and contractile activity and to relax the portal vein muscle strips. At concentrations of 5.10(-6)-5.10(-3) mol/l voltaren caused a dose-dependent relaxation of the cerebral arterial muscle strips. The relaxation of the smooth muscles of the blood vessels induced by voltaren is suggested to be due to inhibition of calcium ions influx into muscle cells through different types of calcium channels.
采用蔗糖间隙法研究了扶他林对兔门静脉和牛脑动脉平滑肌细胞电活动及收缩活动的影响。发现扶他林在浓度为10⁻⁶ - 10⁻³mol/L时可稀疏（10⁻⁶ - 10⁻³mol/L）或抑制（10⁻⁴ - 10⁻³mol/L）自发电活动和收缩活动，并使门静脉肌条松弛。在浓度为5×10⁻⁶ - 5×10⁻³mol/L时，扶他林可使脑动脉肌条产生剂量依赖性松弛。扶他林诱导的血管平滑肌松弛被认为是由于抑制了钙离子通过不同类型钙通道流入肌肉细胞。
