Department of Hepatology, Gastroenterology and Infectious Diseases, Faculty of Medicine Benha University.
Department of Diagnostic and Intervention Radiology, National Liver Institute, Faculty of Medicine, Menoufya University, Egypt.
Eur J Gastroenterol Hepatol. 2021 Mar 1;33(3):407-414. doi: 10.1097/MEG.0000000000001741.
Hepatocellular carcinoma (HCC) has an increasing incidence worldwide, and is considered the second cause of cancer-related death.
The aim of the study is to assess the usefulness of real-time shear-wave elastography in differentiating HCC from other hepatic focal lesions.
The current study was conducted on 110 patients in addition to 10 healthy subjects, divided into four groups as follows: liver cirrhosis, HCC, hepatic focal lesions other than HCC, and control. Demographic, laboratory and imaging data were collected and then elastographic assessment of the hepatic focal lesions and the surrounding liver parenchyma using elastograph point quantification (ElastPQ) (iU22x MATRIX, Philips) was done.
ElastPQ (iU22x MATRIX, Philips) has shown its ability to differentiate between HCC and cystic focal lesions, HCC and cholangiocarcinoma, and HCC and focal nodular hyperplasia (FNH). Cystic lesions demonstrated lower stiffness in comparison to HCC; however, cholangiocarcinoma and FNH demonstrated higher stiffness in comparison to HCC. ElastPQ was unable to differentiate between stiffness in both 'HCC and hemangioma' and 'HCC and metastatic focal lesions'. ElastPQ showed that HCC, cystic focal lesions, and cholangiocarcinoma had lower stiffness in comparison to their surrounding liver parenchyma, whereas FNH had higher stiffness in comparison to the surrounding liver parenchyma. ElastPQ showed that the surrounding liver parenchyma of the HCC group has the highest stiffness amongst all studied hepatic focal lesions surrounding liver parenchyma.
'Point' shear-waves elastography (ElastPQ; Philips iU22x MATRIX, Philips) is a noninvasive, quantitative and nonradiating method for evaluation of tissue elasticity, and is helpful in differentiating HCC from other hepatic focal lesions.
肝细胞癌（HCC）在全球的发病率不断上升，是癌症相关死亡的第二大原因。
本研究旨在评估实时剪切波弹性成像在鉴别 HCC 与其他肝局灶性病变中的作用。
本研究共纳入 110 例患者和 10 例健康对照，分为四组：肝硬化、HCC、非 HCC 肝局灶性病变和对照组。收集患者的人口统计学、实验室和影像学资料，并使用弹性成像点量化（ElastPQ）（iU22x MATRIX，飞利浦）对肝局灶性病变及其周围肝实质进行弹性评估。
ElastPQ（iU22x MATRIX，飞利浦）能够区分 HCC 与囊性局灶性病变、HCC 与胆管细胞癌以及 HCC 与局灶性结节性增生（FNH）。与 HCC 相比，囊性病变的硬度较低；然而，胆管细胞癌和 FNH 的硬度高于 HCC。ElastPQ 无法区分“HCC 与肝血管瘤”和“HCC 与转移性局灶性病变”之间的硬度差异。ElastPQ 显示，与周围肝实质相比，HCC、囊性局灶性病变和胆管细胞癌的硬度较低，而 FNH 的硬度较高。ElastPQ 显示，HCC 组的周围肝实质与所有研究的肝局灶性病变周围肝实质相比具有最高的硬度。
“点”剪切波弹性成像（ElastPQ；飞利浦 iU22x MATRIX，飞利浦）是一种非侵入性、定量、非辐射的组织弹性评估方法，有助于鉴别 HCC 与其他肝局灶性病变。
