麻醉状态下多巴胺对血浆生长激素和催乳素浓度的影响。
Effect of dopamine on plasma growth hormone and prolactin concentrations under anaesthesia.
作者信息
Mikawa K, Kusunoki M, Obara H, Iwai S
机构信息
Department of Anaesthesiology, Kobe University School of Medicine, Japan.
出版信息
J Int Med Res. 1988 Nov-Dec;16(6):403-12. doi: 10.1177/030006058801600601.
Five patients with acromegaly and five patients with prolactinoma undergoing general anaesthesia were studied. Concentrations of plasma growth hormone in patients with acromegaly and concentrations of plasma prolactin in patients with prolactinoma were measured before anaesthesia, when 250 mg levodopa was administered orally, and after anaesthesia when dopamine was infused intravenously at a rate of 5 micrograms/kg.min. There was no difference in hormonal (growth hormone or prolactin) response to either treatment in the anaesthetized and the awake states. These findings indicate that the functioning of dopamine receptors in the anterior pituitary is not affected by anaesthesia.
对五名接受全身麻醉的肢端肥大症患者和五名接受全身麻醉的泌乳素瘤患者进行了研究。在麻醉前、口服250毫克左旋多巴时以及麻醉后以5微克/千克·分钟的速率静脉输注多巴胺时，分别测量了肢端肥大症患者的血浆生长激素浓度和泌乳素瘤患者的血浆泌乳素浓度。在麻醉状态和清醒状态下，两种治疗方法引起的激素（生长激素或泌乳素）反应没有差异。这些发现表明，麻醉不会影响垂体前叶多巴胺受体的功能。
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