Laboratory of Transcription Biology, Molecular Genetics Division, CSIR-Indian Institute of Chemical Biology, 4, Raja S. C. Mullick Road, Kolkata 32, India.
Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, 201002, India.
Biochim Biophys Acta Gene Regul Mech. 2020 Aug;1863(8):194563. doi: 10.1016/j.bbagrm.2020.194563. Epub 2020 Apr 27.
Since the identification of key MLL fusion partners as transcription elongation factors regulating expression of HOX cluster genes during hematopoiesis, extensive work from the last decade has resulted in significant progress in our overall mechanistic understanding of role of MLL fusion partner proteins in transcriptional regulation of diverse set of genes beyond just the HOX cluster. In this review, we are going to detail overall understanding of role of MLL fusion partner proteins in transcriptional regulation and thus provide mechanistic insights into possible MLL fusion protein-mediated transcriptional misregulation leading to aberrant hematopoiesis and leukemogenesis.
自鉴定关键的 MLL 融合伙伴作为转录延伸因子以来，在造血过程中调节 HOX 簇基因的表达，过去十年的广泛研究在我们对 MLL 融合伙伴蛋白在除了 HOX 簇之外的各种基因的转录调控中的作用的整体机制理解方面取得了重大进展。在这篇综述中，我们将详细阐述 MLL 融合伙伴蛋白在转录调控中的作用，从而深入了解可能导致异常造血和白血病发生的 MLL 融合蛋白介导的转录失调的机制。
