在条件性飞行范式中行为反应的性别差异。

Sex differences in behavioral responses during a conditioned flight paradigm.

机构信息

Department of Psychology, Tulane University, New Orleans, LA 70118, USA; Tulane Brain Institute, Tulane University, New Orleans, LA 70118, USA.

Department of Psychology, Tulane University, New Orleans, LA 70118, USA; Tulane Brain Institute, Tulane University, New Orleans, LA 70118, USA; Program in Neuroscience, Tulane University, New Orleans, LA 70118, USA.

出版信息

Behav Brain Res. 2020 Jul 1;389:112623. doi: 10.1016/j.bbr.2020.112623. Epub 2020 Apr 26.

DOI:10.1016/j.bbr.2020.112623

PMID:32348872

Abstract

Females exhibit greater susceptibility to trauma- and stress-related disorders compared to males; therefore, it is imperative to study sex differences in the mode and magnitude of defensive responses in the face of threat. To test for sex differences in defensive behavior, we used a modified Pavlovian fear conditioning paradigm that elicits clear transitions between freezing and flight behaviors within individual subjects. Female mice subjected to this paradigm exhibited more freezing behavior compared to males, especially during the intertrial interval period. Female mice also exhibited more freezing in response to conditioned auditory stimuli in the last block of extinction training. Furthermore, there were sex differences in the expression of other adaptive behaviors during fear conditioning. Assaying rearing, grooming, and tail rattling behaviors during the conditioned flight paradigm yielded measurable differences across sessions and between males and females. Overall, these results provide insight into sex-dependent alterations in mouse behavior induced by fear conditioning.

摘要

女性比男性更容易受到创伤和应激相关障碍的影响；因此，研究面对威胁时防御反应的模式和程度的性别差异至关重要。为了测试防御行为的性别差异，我们使用了改良的巴甫洛夫式恐惧条件反射范式，该范式在个体中引发了明确的冻结和飞行行为之间的转变。与雄性相比，接受这种范式的雌性小鼠表现出更多的冻结行为，尤其是在试验间隔期。雌性小鼠在消退训练的最后一个块中对条件性听觉刺激也表现出更多的冻结。此外，在恐惧条件反射中，其他适应性行为的表达也存在性别差异。在条件性飞行范式中检测饲养、梳理和尾部抖动行为，在整个实验过程中以及雄性和雌性之间都产生了可测量的差异。总的来说，这些结果提供了对由恐惧条件反射引起的小鼠行为的性别依赖性改变的深入了解。