Department of Pharmaceutical Engineering & Technology, Indian Institute of Technology (Banaras Hindu University), Varanasi, 221005, India.
Future Med Chem. 2020 Jun;12(11):1037-1069. doi: 10.4155/fmc-2019-0198. Epub 2020 Apr 30.
Cancer, characterized by uncontrolled malignant neoplasm, is a leading cause of death in both advanced and emerging countries. Although, ample drugs are accessible in the market to intervene with tumor progression, none are totally effective and safe. Natural anthraquinone (AQ) equivalents such as emodin, aloe-emodin, alchemix and many synthetic analogs extend their antitumor activity on different targets including telomerase, topoisomerases, kinases, matrix metalloproteinases, DNA and different phases of cell lines. Nano drug delivery strategies are advanced tools which deliver drugs into tumor cells with minimum drug leakage to normal cells. This review delineates the way AQ derivatives are binding on these targets by abolishing tumor cells to produce anticancer activity and purview of nanoformulations related to AQ analogs.
癌症的特征是不受控制的恶性肿瘤，是发达国家和新兴国家死亡的主要原因。尽管市场上有大量的药物可用于干预肿瘤进展，但没有一种是完全有效和安全的。天然蒽醌（AQ）类似物，如大黄素、芦荟大黄素、alchemix 和许多合成类似物，通过不同的靶点（包括端粒酶、拓扑异构酶、激酶、基质金属蛋白酶、DNA 和细胞周期的不同阶段）发挥其抗肿瘤活性。纳米药物递送策略是先进的工具，可以将药物递送到肿瘤细胞中，同时最大限度地减少药物泄漏到正常细胞中。本综述描述了 AQ 衍生物通过阻止肿瘤细胞产生抗癌活性来结合这些靶点的方式，以及与 AQ 类似物相关的纳米制剂的范围。
