West African Centre for Cell Biology of Infectious Pathogens, College of Basic and Applied Sciences, University of Ghana, Legon LG54, Ghana.
Department of Biochemistry, Cell and Molecular Biology, College of Basic and Applied Sciences, University of Ghana, Legon LG54, Ghana.
Exp Biol Med (Maywood). 2020 May;245(9):815-822. doi: 10.1177/1535370220921118. Epub 2020 Apr 29.
Genetic association studies can determine the effect size of gene loci on disease outcomes. In the arena of HBV infections, HLA alleles that associate with HBV outcomes can be used in clinical management decisions. This potential translational utility can shape the future management of HBV infections by identifying at-risk individuals and tailoring medical interventions accordingly. This precision medicine motif is currently only a nascent idea. However, it has stakes that may well override the current "wait and see" approach of clinical management of HBV infections. Here, we have identified HLA alleles associated with HBV outcome in a Ghanaian cohort. Our findings support the motif that HLA alleles associate with HBV outcome along geo-ethnic lines. This buttresses the need for further population pivoted studies. In the long term, our findings add to efforts towards the development of an HLA molecular-based algorithm for predicting HBV infection outcomes.
遗传关联研究可以确定基因座对疾病结果的影响大小。在乙型肝炎病毒 (HBV) 感染领域，与 HBV 结果相关的 HLA 等位基因可用于临床管理决策。这种潜在的转化效用可以通过识别高危个体并相应地调整医疗干预措施来塑造 HBV 感染的未来管理。这种精准医疗模式目前只是一个初步的想法。然而，它的利害关系很可能超过目前 HBV 感染临床管理的“等待观察”方法。在这里，我们在加纳队列中确定了与 HBV 结果相关的 HLA 等位基因。我们的研究结果支持 HLA 等位基因与 HBV 结果在地理民族线上相关的模式。这就需要进一步开展以人群为中心的研究。从长远来看，我们的研究结果为开发基于 HLA 分子的算法预测 HBV 感染结果的努力做出了贡献。
