Epstein-Rigbi Na'ama, Goldberg Michael R, Levy Michael B, Nachshon Liat, Elizur Arnon
Institute of Allergy, Immunology and Pediatric Pulmonology, Shamir (former Assaf Harofeh) Medical Center, Zerifin, Israel.
Department of Pediatrics, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel.
Allergy. 2020 Oct;75(10):2623-2632. doi: 10.1111/all.14350. Epub 2020 May 22.
Oral immunotherapy (OIT) for food allergy improves the quality of life (QOL) of children from parental perspective but little is known about the child perception.
The Food Allergy Quality of Life Questionnaire-Child Form (FAQLQ-CF) was administered to children aged 8-12 years, and the FAQLQ-Parent Form (FAQLQ-PF) was administered to their parents at the start of OIT for milk, egg, peanut, sesame, or tree nuts, at the end of up-dosing, and after 6 months of follow-up. Food-allergic children not undergoing OIT served as controls. Children QOL scores were compared to their parents.
The total FAQLQ-CF score of 103 children undergoing OIT improved significantly from start of OIT (median (IQR); 4.8, 3.8-5.7) to end of up-dosing (3.9, 3-5.2) (P < .001). A greater improvement was noted in the 56 children who reached a follow-up visit, from 5.0 (3.7-5.8) at OIT start to 3.1 (1.8-5.0) on follow-up, (P < .001). In contrast, FAQLQ-CF scores of control patients improved mildly and nonsignificantly between the two time points from 5.3 (4.3-5.7) to 4.8 (3.6-6.0), (P = .13). The improvement in the total FAQLQ-CF scores from OIT start to follow-up was significantly greater compared to the change in control patients during observation (P = .015). Parents reported better QOL scores compared to their children at all stages of OIT (start 4.0, 3.2-5, P = .004; end of up-dosing 2.9, 1.9-4.7, P = .04; follow-up 2.2, 1.6-3.6, P = .003).
QOL of food-allergic children undergoing OIT improves significantly compared to controls. Parents perceive QOL to be better than the perception of the children.
从家长的角度来看，食物过敏的口服免疫疗法（OIT）可改善儿童的生活质量（QOL），但对于儿童自身的感受了解甚少。
在对牛奶、鸡蛋、花生、芝麻或坚果进行OIT治疗开始时、强化剂量结束时以及随访6个月后，对8至12岁的儿童进行食物过敏生活质量问卷儿童版（FAQLQ-CF）评估，并对其父母进行食物过敏生活质量问卷家长版（FAQLQ-PF）评估。未接受OIT治疗的食物过敏儿童作为对照。比较儿童的生活质量评分与他们父母的评分。
103名接受OIT治疗的儿童的FAQLQ-CF总分从OIT开始时（中位数（四分位间距）；4.8，3.8 - 5.7）显著提高到强化剂量结束时（3.9，3 - 5.2）（P <.001）。在56名进行随访的儿童中观察到更大的改善，从OIT开始时的5.0（3.7 - 5.8）提高到随访时的3.1（1.8 - 5.0），（P <.001）。相比之下，对照患者的FAQLQ-CF评分在两个时间点之间略有改善且无统计学意义，从5.3（4.3 - 5.7）降至4.8（3.6 - 6.0），（P =.13）。与观察期间对照患者的变化相比，从OIT开始到随访时FAQLQ-CF总分的改善显著更大（P =.015）。在OIT的所有阶段，家长报告的生活质量评分均高于他们的孩子（开始时4.0，3.2 - 5，P =.004；强化剂量结束时2.9，1.9 - 4.7，P =.04；随访时2.2，1.6 - 3.6，P =.003）。
与对照组相比，接受OIT治疗的食物过敏儿童的生活质量有显著改善。家长认为生活质量比儿童的感受更好。
