Moss Sean, Boucher Helen W
Division of Geographic Medicine and Infectious Diseases, Tufts Medical Center and Tufts University School of Medicine, Boston, Massachusetts, USA.
Open Forum Infect Dis. 2020 Mar 23;7(4):ofaa104. doi: 10.1093/ofid/ofaa104. eCollection 2020 Apr.
The year 2019 brought about a multitude of innovations in clinical infectious diseases. With the continued rise of antimicrobial resistance (AMR), advances in diagnostics and newly available antibiotics offer additional strategies for combating this threat, but the broken antibiotic market serves as an impediment to further developments. The IDSA and other stakeholders are working to create novel pull incentives to stabilize the pipeline. Ongoing needs include developing optimal stewardship practices, including by using narrow-spectrum antibiotics and shorter durations of therapy. In the area of solid organ transplantation, early data from transplanting Hepatitis C virus (HCV)-infected organs are encouraging and the American Society of Transplantation (AST) released new guidelines addressing several key issues. Lastly, 2019 saw a resurgence in Measles emphasizing the importance of vaccination.
2019年临床传染病领域出现了众多创新成果。随着抗菌药物耐药性（AMR）持续上升，诊断技术的进步和新出现的抗生素为应对这一威胁提供了更多策略，但抗生素市场的不景气阻碍了进一步的发展。美国感染病学会（IDSA）和其他利益相关者正在努力创造新的拉动激励措施，以稳定研发流程。当前的需求包括制定最佳管理措施，包括使用窄谱抗生素和缩短治疗疗程。在实体器官移植领域，移植丙型肝炎病毒（HCV）感染器官的早期数据令人鼓舞，美国移植学会（AST）发布了针对几个关键问题的新指南。最后，2019年麻疹疫情卷土重来，凸显了疫苗接种的重要性。
