前蛋白转化酶枯草溶菌素/克新蛋白酶9型与阿尔茨海默病之间的潜在联系。
Potential Link Between Proprotein Convertase Subtilisin/Kexin Type 9 and Alzheimer's Disease.
作者信息
Ce Oldham, Rs Powell, Ab Williams, S Dixon, Cj Wooten, Qm Melendez, D Lopez
机构信息
Department of Pharmaceutical Sciences, Biomanufacturing Research Institute and Technology Enterprise [BRITE], College of Arts and Sciences, North Carolina Central University, Durham, USA.
出版信息
Int J Biomed Investig. 2018;1(1). doi: 10.31531/2581-4745.1000106. Epub 2018 Mar 27.
Alzheimer's disease [AD] is not only the most common neurodegenerative disease but is also currently incurable. Proprotein convertase subtilisin/kexin-9 [PCSK9] is an indirect regulator of plasma low density lipoprotein [LDL] levels controlling LDL receptor expression at the plasma membrane. PCSK9 also appears to regulate the development of glucose intolerance, insulin resistance, abdominal obesity, inflammation, and hypertension, conditions that have been identified as risk factors for AD. PCSK9 levels also depend on age, sex, and ethnic background, factors associated with AD. Herein, we will review indirect evidence that suggests a link between PCSK9 levels and AD.
阿尔茨海默病（AD）不仅是最常见的神经退行性疾病，而且目前无法治愈。前蛋白转化酶枯草溶菌素/kexin-9（PCSK9）是血浆低密度脂蛋白（LDL）水平的间接调节因子，可控制细胞膜上LDL受体的表达。PCSK9似乎还能调节葡萄糖耐量异常、胰岛素抵抗、腹型肥胖、炎症和高血压的发展，这些情况已被确定为AD的危险因素。PCSK9水平还取决于年龄、性别和种族背景，这些因素都与AD相关。在此，我们将综述提示PCSK9水平与AD之间存在联系的间接证据。
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