Barakat H A, Burton D S, Carpenter J W, Holbert D, Israel R G
Department of Biochemistry, East Carolina University, Greenville, NC 27858.
Int J Obes. 1988;12(5):473-80.
Recent studies have related waist to hip ratio (WHR) to the incidence of coronary heart disease (CHD), but the causes underlying this relation are not fully known. The purpose of this study was to determine if waist to hip ratio is associated with the concentration of plasma lipids and apolipoproteins (apoproteins) that predispose individuals to a higher CHD risk. Plasma lipids and apoprotein concentrations were determined in 100 male volunteers, ranging in age from 19-68 yr, and WHR ranging from 0.89-1.09. Significant positive associations were found between WHR, plasma glucose (r = 0.25, P = 0.01), cholesterol (r = 0.21, P = 0.04), LDL cholesterol (r = 0.22, P = 0.03), triglycerides (r = 0.25, P = 0.01) and the ratio of total cholesterol to HDL-cholesterol (r = 0.30, P = 0.002). Negative associations were found between WHR and HDL-cholesterol (r = -0.19, P = 0.05), plasma apoprotein A-I (4 = -0.28, P = 0.005) and the ratio of plasma apoprotein A-I to apoprotein B (r = -0.26, P = 0.01). To determine the extent to which these correlations were independent of age and body fat content, a subsample of 15 pairs matched on age and percent body fat, but differing in WHR was selected from the larger sample. In the group with high WHR (1.06) HDL-cholesterol and apo A-I levels were lower and apo B higher than in the group with low WHR (0.96). Total cholesterol, triglycerides and LDL cholesterol levels in the group with high WHR were also higher but marginally significant statistically. These results show that WHR is associated with plasma lipid and apolipoprotein concentrations that are more predisposing to CHD and that males with male type obesity may be at a higher risk of CHD development than those with female type, regardless of age or degree of obesity.
近期研究已将腰臀比（WHR）与冠心病（CHD）的发病率联系起来，但这种关联背后的原因尚未完全明确。本研究的目的是确定腰臀比是否与血浆脂质和载脂蛋白的浓度相关，而这些因素会使个体患冠心病的风险更高。对100名年龄在19至68岁之间、腰臀比在0.89至1.09之间的男性志愿者测定了血浆脂质和载脂蛋白浓度。结果发现，腰臀比与血浆葡萄糖（r = 0.25，P = 0.01）、胆固醇（r = 0.21，P = 0.04）、低密度脂蛋白胆固醇（r = 0.22，P = 0.03）、甘油三酯（r = 0.25，P = 0.01）以及总胆固醇与高密度脂蛋白胆固醇的比值（r = 0.30，P = 0.002）之间存在显著的正相关。腰臀比与高密度脂蛋白胆固醇（r = -0.19，P = 0.05）、血浆载脂蛋白A-I（r = -0.28，P = 0.005）以及血浆载脂蛋白A-I与载脂蛋白B的比值（r = -0.26，P = 0.01）之间存在负相关。为了确定这些相关性在多大程度上独立于年龄和体脂含量，从较大样本中选取了15对年龄和体脂百分比匹配但腰臀比不同的样本。在高腰臀比组（1.06）中，高密度脂蛋白胆固醇和载脂蛋白A-I水平低于低腰臀比组（0.96），而载脂蛋白B水平更高。高腰臀比组中的总胆固醇、甘油三酯和低密度脂蛋白胆固醇水平也更高，但在统计学上仅略有显著性。这些结果表明，腰臀比与更易引发冠心病的血浆脂质和载脂蛋白浓度相关，并且无论年龄或肥胖程度如何，男性型肥胖男性患冠心病的风险可能高于女性型肥胖男性。
