Brown University, Department of Cognitive, Linguistic, and Psychological Sciences, Providence, RI 02912, USA.
Trends Neurosci. 2020 May;43(5):300-310. doi: 10.1016/j.tins.2020.02.004. Epub 2020 Mar 16.
Sex as a biological variable (SABV) is critical for understanding the broad range of physiological, neurobiological, and behavioral consequences of early life adversity(ELA). The study of the interaction of SABV and ELA ties into several current debates, including the importance of taking into account SABV in research, differing strategies employed by males and females in response to adversity, and the possible evolutionary and developmental mechanisms of altered development in response to adversity. This review highlights the importance of studying both sexes, of understanding sex differences (and similarities) in response to ELA, and provides a context for the debate surrounding whether the response to ELA may be an adaptive process.
性别作为一个生物学变量（SABV）对于理解早期生活逆境（ELA）对生理、神经生物学和行为的广泛影响至关重要。研究 SABV 与 ELA 的相互作用涉及到几个当前的争论，包括在研究中考虑 SABV 的重要性、男女在应对逆境时采用的不同策略，以及对逆境的改变发育的可能进化和发育机制。这篇综述强调了研究两性的重要性，以及理解对 ELA 的反应中的性别差异（和相似性），并为围绕 ELA 的反应是否可能是一种适应性过程的争论提供了背景。
