成人髓母细胞瘤挽救性再放疗选择：病例报告及文献复习。
Salvage Re-irradiation Options in Adult Medulloblastoma: A Case Report and Review of the Literature.
机构信息
Radiation Oncology School, University of Palermo, Palermo, Italy
Advanced Radiation Oncology Department, IRCCS Sacro Cuore Don Calabria Hospital, Verona, Italy.
出版信息
In Vivo. 2020 May-Jun;34(3):1283-1288. doi: 10.21873/invivo.11903.
BACKGROUND/AIM: Medulloblastoma is a rare tumor of adult age, while it occurs more frequently in children. Given the rarity, there is a lack of evidence for the treatment of recurrent disease. Few data are available about salvage re-irradiation collecting very heterogeneous series.
CASE REPORT
A 51-year-old male presented with headache, nausea, double vision, and gait disorders. A contrast-enhanced brain-MRI showed the presence of multifocal medulloblastoma. After surgery, adjuvant craniospinal radiotherapy was performed, chemotherapy was stopped due to toxicity. After 27 months, a new MRI and a Methionine-PET revealed a late pontocerebellar relapse; multidisciplinary board decided for a SBRT treatment. The second course of RT was well tolerated and 14 months later, the patient is alive in good general conditions, with no evidence of disease.
CONCLUSION
Our experience supports the use of salvage stereotactic radiotherapy as a safe and effective treatment option.
背景/目的：成神经管细胞瘤是一种罕见的成人肿瘤，而在儿童中更为常见。鉴于其罕见性，对于复发性疾病的治疗缺乏证据。关于挽救性再放疗的资料很少，且收集的系列非常混杂。
病例报告
一名 51 岁男性出现头痛、恶心、复视和步态障碍。增强脑 MRI 显示有多发性成神经管细胞瘤。手术后，进行了颅脊髓辅助放疗，由于毒性作用停止了化疗。27 个月后，新的 MRI 和蛋氨酸-PET 显示桥脑小脑后复发；多学科委员会决定进行 SBRT 治疗。第二次放疗过程耐受良好，14 个月后，患者情况良好，一般状况良好，无疾病证据。
结论
我们的经验支持使用挽救性立体定向放疗作为一种安全有效的治疗选择。
Zotero 插件