Division of Breast and Endocrine Surgery, Department of General Surgical Science, Graduate School of Medicine, Gunma University, Gunma, Japan
Division of Breast and Endocrine Surgery, Department of General Surgical Science, Graduate School of Medicine, Gunma University, Gunma, Japan.
In Vivo. 2020 May-Jun;34(3):1365-1369. doi: 10.21873/invivo.11915.
BACKGROUND/AIM: We investigated the relationship between F18-fluorodeoxyglucose (FDG) uptake and the platelet/lymphocyte ratio (PLR), as both represent inflammation.
We retrospectively analyzed the cases of 143 consecutive invasive ductal carcinoma patients who had undergone preoperative FDG-PET and surgery. We divided the patients into groups based on their maximum standardized uptake value (SUVmax) values: low (<2.5) and high (≥2.5) and based on their PLRs: low (<130) and high (≥130). We determined the relationships between the SUVmax or PLR and clinicopathological features.
Seventy-three patients (51.0%) had a high SUVmax in their primary tumor. There were significant associations between SUVmax and the PLR. A multivariate analysis revealed that high PLR, but not NLR, was independent factor associated with a high SUVmax. Seventy-four patients (51.7%) had a high PLR; The factors significantly associated with high PLR were large tumor size, presence of node metastasis, presence of vascular invasion, high NLR, and high SUVmax.
In breast cancer patients, the PLR is independently associated with the SUVmax, but not with recurrent disease. In breast cancer patients with a high SUVmax and/or PLR, these values may reflect the tumor microenvironment.
背景/目的：我们研究了 F18-氟脱氧葡萄糖（FDG）摄取与血小板/淋巴细胞比值（PLR）之间的关系，因为两者都代表炎症。
我们回顾性分析了 143 例连续接受术前 FDG-PET 和手术的浸润性导管癌患者的病例。我们根据最大标准化摄取值（SUVmax）将患者分为低（<2.5）和高（≥2.5）组，并根据 PLR 分为低（<130）和高（≥130）组。我们确定了 SUVmax 或 PLR 与临床病理特征之间的关系。
73 例（51.0%）患者原发肿瘤 SUVmax 较高。SUVmax 与 PLR 之间存在显著相关性。多因素分析显示，高 PLR 是与 SUVmax 升高相关的独立因素，而 NLR 则不然。74 例（51.7%）患者 PLR 较高；与 PLR 升高显著相关的因素是肿瘤体积大、有淋巴结转移、有血管侵犯、高 NLR 和高 SUVmax。
在乳腺癌患者中，PLR 与 SUVmax 独立相关，但与复发无关。在 SUVmax 和/或 PLR 较高的乳腺癌患者中，这些值可能反映了肿瘤微环境。
