Operation Eyesight Universal Institute for Eye Cancer, LV Prasad Eye Institute, Hyderabad, India.
Cornea. 2021 Feb 1;40(2):142-146. doi: 10.1097/ICO.0000000000002350.
To study the efficacy of interferon alfa-2b (IFN-a2b) on pigmented ocular surface squamous neoplasia (p-OSSN) and assess the resolution of the pigment to the treatment.
A retrospective case series of 8 tumors in 7 patients.
The mean age at diagnosis of p-OSSN was 65 years (median, 61 years; range, 51-84 years), and all patients were men. The mean duration of symptoms was 2 months (median, 1 month; range, 1-4 months). One patient had 2 distinct lesions in the same eye. Tumor epicenter was located at the limbus (n = 5) or bulbar conjunctiva (n = 2). Complexion-associated melanosis was noted in all eyes. The mean basal dimension of the tumor was 8 mm (median, 7 mm; range, 5-12 mm). The mean % of tumor pigmentation was 47% (median, 30%; range, 10%-100%). The treatment details included topical IFN-a2b (n = 1) or a combination of topical and subconjunctival injection of IFN-a2b (n = 7). All patients with p-OSSN showed excellent response to IFN-a2b with complete tumor regression and resolution of tumor-associated pigment with a mean number of 2 subconjunctival IFN-a2b injections (median, 2; range, 0-3) and topical IFN-a2b for an average of 2 months (median, 2 months; range, 1-3 months). There was no change in the complexion-associated melanosis with IFN-a2b.
IFN-a2b is very effective in the management of p-OSSN. There is a complete resolution of the pigment along with the tumor.
研究干扰素 α-2b（IFN-a2b）治疗色素性眼表鳞状上皮瘤（p-OSSN）的疗效，并评估色素消退与治疗的关系。
回顾性病例系列研究，纳入 7 例患者的 8 个肿瘤。
p-OSSN 的诊断平均年龄为 65 岁（中位数为 61 岁；范围为 51-84 岁），所有患者均为男性。症状持续的平均时间为 2 个月（中位数为 1 个月；范围为 1-4 个月）。1 例患者同一只眼有 2 个不同的病变。肿瘤中心位于角膜缘（n=5）或球结膜（n=2）。所有眼睛均有肤色相关的黑色素沉着。肿瘤的平均基底直径为 8 毫米（中位数为 7 毫米；范围为 5-12 毫米）。肿瘤色素沉着的平均百分比为 47%（中位数为 30%；范围为 10%-100%）。治疗详情包括局部应用 IFN-a2b（n=1）或局部和球结膜下联合应用 IFN-a2b（n=7）。所有 p-OSSN 患者对 IFN-a2b 反应良好，肿瘤完全消退，肿瘤相关色素完全消退，平均需行 2 次球结膜下 IFN-a2b 注射（中位数为 2 次；范围为 0-3 次），局部应用 IFN-a2b 平均 2 个月（中位数为 2 个月；范围为 1-3 个月）。肤色相关黑色素沉着无变化。
IFN-a2b 治疗 p-OSSN 非常有效。肿瘤和色素均可完全消退。
