Department of Orthopedic Surgery, Singapore General Hospital, Singapore, Singapore.
Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
J Knee Surg. 2021 Oct;34(12):1359-1367. doi: 10.1055/s-0040-1709488. Epub 2020 Apr 30.
This study aims to find out if routine preoperative group crossmatch and postoperative check hemoglobin for total knee arthroplasty (TKA) patients is necessary. A retrospective analysis was performed on patients who underwent unilateral TKAs for osteoarthritis from January 1, 2004 to December 31, 2014. The main outcome measures were postoperative hemoglobin levels and transfusion requirements. Patients' demographics, comorbidities, laboratory results, and surgical details were analyzed. A total of 955 TKAs were included in this study (males = 207, females = 748; mean age = 66.1 years, standard deviation [SD] = 7.7). A total of 79 (8.27%) cases required postoperative blood transfusion, and the crossmatch-transfusion ratio was 17.5. Significant predictors for postoperative transfusion included lower preoperative hemoglobin levels ( < 0.001) and advanced age ( < 0.001). Receiver operating characteristic (ROC) curve and Youden's Index analyses identified the preoperative hemoglobin cut-off value for females to be 12.1 g/dL (relative risk (RR): 5.65, < 0.001) in predicting postoperative blood transfusion requirement, and 12.4 g/dL (RR: 11.71, < 0.001) for males. For age, the identified cut-off value was 68 years (RR: 3.18, < 0.001). The largest decline in hemoglobin levels was noted on postoperative day (POD) 3 (31.8%), and smallest on POD 1 (18.8%). The postoperative transfusion requirements in TKA are low and do not justify routine perioperative blood investigations. However, these investigations should be reserved for patients with the identified risk factors, in particular advancing age (68 years and above) and lower preoperative hemoglobin (below or equal to 12.1 and 12.4 g/dL for females and males, respectively). In the event that postoperative hemoglobin level needs to be checked, it should be performed beyond the first POD.
本研究旨在探讨全膝关节置换术(TKA)患者是否需要常规进行术前配血和术后血红蛋白检查。对 2004 年 1 月 1 日至 2014 年 12 月 31 日期间因骨关节炎行单侧 TKA 的患者进行回顾性分析。主要观察指标为术后血红蛋白水平和输血需求。分析患者的人口统计学、合并症、实验室结果和手术细节。本研究共纳入 955 例 TKA(男性 207 例,女性 748 例;平均年龄 66.1 岁,标准差 [SD]7.7)。共 79 例(8.27%)患者术后需要输血,配血-输血比为 17.5。术后输血的显著预测因素包括术前血红蛋白水平较低( < 0.001)和年龄较大( < 0.001)。接受者操作特征(ROC)曲线和 Youden 指数分析确定女性术前血红蛋白临界值为 12.1 g/dL(相对风险 [RR]:5.65, < 0.001),可预测术后输血需求,男性临界值为 12.4 g/dL(RR:11.71, < 0.001)。对于年龄,确定的临界值为 68 岁(RR:3.18, < 0.001)。血红蛋白水平最大降幅出现在术后第 3 天(31.8%),最小降幅出现在术后第 1 天(18.8%)。TKA 术后输血需求较低,常规围手术期血液检查无必要。但是,这些检查应保留给有明确危险因素的患者,特别是年龄较大(68 岁及以上)和术前血红蛋白较低(女性分别为低于或等于 12.1 和 12.4 g/dL,男性分别为低于或等于 12.1 和 12.4 g/dL)。如果需要检查术后血红蛋白水平,应在术后第 1 天之后进行。