Center for Reproductive Biology, School of Molecular Biosciences, College of Veterinary Medicine, Washington State University, Pullman, WA, USA.
Andrology. 2020 Jul;8(4):852-861. doi: 10.1111/andr.12810. Epub 2020 May 24.
The germline serves as a conduit for transmission of genetic and epigenetic information from one generation to the next. In males, spermatozoa are the final carriers of inheritance and their continual production is supported by a foundational population of spermatogonial stem cells (SSCs) that forms from prospermatogonial precursors during the early stages of neonatal development. In mammals, the timing for which SSCs are specified and the underlying mechanisms guiding this process remain to be completely understood.
To propose an evolving concept for how the foundational SSC population is established.
This review summarizes recent and historical findings from peer-reviewed publications made primarily with mouse models while incorporating limited studies from humans and livestock.
Establishment of the SSC population appears to follow a biphasic pattern involving a period of fate programming followed by an establishment phase that culminates in formation of the SSC population. This model for establishment of the foundational SSC population from precursors is anticipated to extend across mammalian species and include humans and livestock, albeit on different timescales.
种系作为遗传和表观遗传信息从一代传递到下一代的通道。在男性中，精子是遗传的最终载体，其持续产生由新生儿发育早期的前生殖细胞祖细胞形成的基础精原干细胞（SSC）群体支持。在哺乳动物中，SSC 被指定的时间以及指导这一过程的潜在机制仍有待完全理解。
提出一个关于基础 SSC 群体如何建立的发展概念。
本综述总结了主要使用小鼠模型的同行评审出版物中的最新和历史发现，同时纳入了来自人类和家畜的有限研究。
SSC 群体的建立似乎遵循双相模式，包括一个命运编程期，随后是一个建立期，最终形成 SSC 群体。这种从前体建立基础 SSC 群体的模型预计将扩展到哺乳动物物种，包括人类和家畜，但时间尺度不同。
