Modest Jacob M, Raducha Jeremy E, Testa Edward J, Eberson Craig P
Department of Orthopaedic Surgery, Alpert Medical School of Brown University/Rhode Island Hospital, Providence, RI.
Chief, Division of Pediatric Orthopedics, Hasbro Children's Hospital; Associate Professor of Orthopaedic Surgery, Alpert Medical School of Brown University/Rhode Island Hospital, Providence, RI.
R I Med J (2013). 2020 May 1;103(4):19-22.
The prevalence of amputation and post-amputation pain (PAP) is rising. There are two main types of PAP: residual limb pain (RLP) and phantom limb pain (PLP), with an estimated 95% of people with amputations experiencing one or both. Medical Management: The majority of chronic PAP is due to phantom limb pain, which is neurogenic in nature. Common medications used include tricyclic antidepressants, gabapentin, and opioids. Newer studies are evaluating alternative drugs such as ketamine and local anesthetics. Rehabilitation Management: Mirror visual feedback and cognitive behavioral therapy are often effective adjunct therapies and have minimal adverse effects. Surgical Management: Neuromodulatory treatment and surgery for neuromas have been found to help select patients with PAP.
PAP is a complex condition with mechanisms that can be located at the residual limb, spinal cord, and brain - or a combination. This complex pain can be difficult to treat. The mainstays of treatment are largely medical, but several surgical options are also being studied.
截肢及截肢后疼痛(PAP)的患病率正在上升。PAP主要有两种类型:残肢痛(RLP)和幻肢痛(PLP),估计95%的截肢患者会经历其中一种或两种疼痛。
大多数慢性PAP是由幻肢痛引起的,其本质是神经性的。常用药物包括三环类抗抑郁药、加巴喷丁和阿片类药物。最新研究正在评估氯胺酮和局部麻醉剂等替代药物。
镜像视觉反馈和认知行为疗法通常是有效的辅助疗法,且副作用最小。
已发现神经调节治疗和神经瘤手术有助于部分患有PAP的患者。
PAP是一种复杂的病症,其机制可能位于残肢、脊髓和大脑,或这些部位的组合。这种复杂的疼痛难以治疗。治疗的主要方法很大程度上是医学手段,但也在研究几种手术选择。