传统锯齿状腺瘤（TSA）及其相关病变：TSA 的存在预示着高级别肿瘤状态。
Traditional serrated adenomas (TSA) and the company they keep: TSA presence predicts advanced neoplasm states.
机构信息
Department of Internal Medicine, University of California Irvine Medical Center, 101 The City Drive, City Tower, Suite 400, Orange, CA, 92806, USA.
Department of Gastroenterology, University of California Irvine Medical Center, Orange, CA, USA.
出版信息
Int J Colorectal Dis. 2020 Jul;35(7):1351-1354. doi: 10.1007/s00384-020-03587-x. Epub 2020 May 1.
BACKGROUND
The association of TSAs with metachronous neoplasms is well established and suggests that TSAs would also have an association with synchronous neoplasms.
METHODS
We compared odds ratios and rates of synchronous neoplasms found in colonoscopies with and without TSAs.
RESULTS
There was a mean of 2.44 neoplasms among TSA cases in comparison with 1.72 in non-TSA cases. The odds ratio for advanced neoplasia was highest among cases with one or more TSAs relative to cases with one or more HPs (7.54 [CI, 4.23-13.44]) when compared with adenomas (1.95 [CI, 1.75-2.17]) and SSPs (2.98 [CI, 2.54-3.5]).
CONCLUSIONS
In this study population, there is a 7-fold higher risk of synchronous advanced neoplasms among cases with one or more TSAs.
背景
TSA 与同时性肿瘤的相关性已得到充分证实，这表明 TSA 也与异时性肿瘤相关。
方法
我们比较了有和没有 TSA 的结肠镜检查中同时性肿瘤的比值比和发生率。
结果
与非 TSA 病例相比，TSA 病例中有 2.44 个肿瘤，而非 TSA 病例中有 1.72 个肿瘤。与腺瘤（1.95 [CI，1.75-2.17]）和 SSPs（2.98 [CI，2.54-3.5]）相比，一个或多个 TSA 病例发生高级别肿瘤的比值比最高（7.54 [CI，4.23-13.44]）。
结论
在本研究人群中，一个或多个 TSA 病例发生同步高级别肿瘤的风险增加了 7 倍。
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