Hirai Y, Kaku S, Shimizu Y, Nakayama K, Teshima H, Chen J T, Hamada T, Fujimoto I, Yamauchi K, Hasumi K
Department of Gynecology, Cancer Institute Hospital, Tokyo.
Nihon Sanka Fujinka Gakkai Zasshi. 1988 Nov;40(11):1707-10.
From 1971 to 1985, peritoneal cytologic examination was performed at the time of operation in 235 previously untreated patients with endometrial carcinoma. The relationship between the cytologic findings and prognoses by stage was investigated. The results were as follows: 1. In the peritoneal cytologic examination, 44 (18.7%) out of 235 cases were positive for cancer cells in all stages, 25 (14.5%) out of 173 cases in stage I, 7 (21.2%) out of 33 cases in stage II, and 8 (32.0%) out of 25 cases in stage III. 2. Among the 20 cases of stage I endometrial carcinoma that had no macroscopic metastasis and had positive peritoneal cytologic findings for cancer cells, 5- and 10-year cumulative survival rates were 94.7 and 94.7%, against 92.7% and 90.9% in cases with negative peritoneal cytology respectively. The recurrence rate in the same stage was 12.0% for positive cases, against 9.5% for negative cases. No significant differences between positive and negative cases were found. 3. In stages II and III, the difference between the survival rates for 9 cases which have positive peritoneal cytology without macroscopic peritoneal metastasis and 47 cases with negative peritoneal cytology were not statistically significant. 4. In endometrial carcinoma without macroscopic peritoneal metastasis, the appearance of cancer cells in peritoneal cytologic examination is not correlated with the prognosis.
1971年至1985年期间，对235例未经治疗的子宫内膜癌患者在手术时进行了腹腔细胞学检查。研究了细胞学检查结果与各期预后之间的关系。结果如下：1. 在腹腔细胞学检查中，235例患者中各期共有44例（18.7%）癌细胞呈阳性，Ⅰ期173例中有25例（14.5%），Ⅱ期33例中有7例（21.2%），Ⅲ期25例中有8例（32.0%）。2. 在20例Ⅰ期子宫内膜癌患者中，无肉眼可见转移且腹腔细胞学检查癌细胞呈阳性，其5年和10年累积生存率分别为94.7%和94.7%，而腹腔细胞学检查阴性的患者分别为92.7%和90.9%。同一期阳性病例的复发率为12.0%，阴性病例为9.5%。阳性和阴性病例之间未发现显著差异。3. 在Ⅱ期和Ⅲ期，腹腔细胞学检查阳性但无肉眼可见腹腔转移的9例患者与腹腔细胞学检查阴性的47例患者的生存率差异无统计学意义。4. 在无肉眼可见腹腔转移的子宫内膜癌中，腹腔细胞学检查中癌细胞的出现与预后无关。
