Department of Nursing, Kagoshima Medical Association Hospital, Kagoshima, Japan.
Department of Rehabilitation Medicine, Kumamoto Rehabilitation Hospital, Kumamoto, Japan.
JPEN J Parenter Enteral Nutr. 2021 Feb;45(2):372-380. doi: 10.1002/jpen.1845. Epub 2020 May 2.
Dysphagia following heart failure (HF) has gained little attention. This study aimed to evaluate the incidence of dysphagia and its associations with the clinical outcomes in HF patients.
This prospective cohort study included 203 consecutive hospitalized HF patients (mean age 79.5 years, 103 women) without dysphagia before admission. Dysphagia or difficulty swallowing was assessed by the Food Intake Level Scale. The primary outcome was activity of daily living, as assessed by the Barthel Index (BI) at discharge. Secondary outcomes included all-cause mortality and rehospitalization rates at 1 year after discharge. Multivariate analyses and Kaplan-Meier estimates were used to determine whether dysphagia was associated with these outcomes.
Of the 203 patients examined, 48 (23.4%) were diagnosed with dysphagia during admission. Patients who developed dysphagia were significantly older, exhibited lower muscle mass and strength, walked shorter distances, and had lower nutrition intake levels and BI scores (P < 0.05 for all values) compared with those without dysphagia. In the multivariate analyses, the presence of dysphagia at discharge was significantly associated with a lower BI (β= -0.275, P < 0.001). Furthermore, patients with dysphagia showed a significantly higher 1-year mortality than those without (20.8% vs 1.2%, P = 0.008).
Dysphagia commonly occurs during hospital admission and is associated with functional recovery and 1-year mortality in HF patients.
心力衰竭(HF)后吞咽困难(Dysphagia)受到的关注较少。本研究旨在评估 HF 患者吞咽困难的发生率及其与临床结局的关系。
这项前瞻性队列研究纳入了 203 例连续住院的 HF 患者(平均年龄 79.5 岁,103 例女性),入院前无吞咽困难。通过饮食摄入水平量表评估吞咽困难或吞咽困难。主要结局是日常生活活动能力,出院时用巴氏指数(BI)评估。次要结局包括出院后 1 年的全因死亡率和再住院率。采用多变量分析和 Kaplan-Meier 估计来确定吞咽困难是否与这些结局相关。
在 203 例患者中,48 例(23.4%)在住院期间被诊断为吞咽困难。与无吞咽困难的患者相比,发生吞咽困难的患者年龄更大,肌肉质量和力量更低,行走距离更短,营养摄入量和 BI 评分更低(所有 P 值均<0.05)。在多变量分析中,出院时存在吞咽困难与 BI 较低显著相关(β=-0.275,P<0.001)。此外,吞咽困难患者的 1 年死亡率明显高于无吞咽困难患者(20.8% vs 1.2%,P=0.008)。
吞咽困难在住院期间很常见,与 HF 患者的功能恢复和 1 年死亡率相关。