严重动脉粥样硬化和广泛性动脉瘤疾病中血清KLF4升高。

Increased Serum KLF4 in Severe Atheromatosis and Extensive Aneurysmal Disease.

作者信息

Bakoyiannis Christos, Mylonas Konstantinos S, Papoutsis Konstantinos, Kakavia Kyriaki, Schizas Dimitrios, Iliopoulos Dimitrios, Nikiteas Nikolaos, Liakakos Theodoros, Kapelouzou Alkistis

机构信息

Division of Vascular Surgery, Laikon General Hospital, National and Kapodistrian University of Athens, Athens, Greece.

First Department of Surgery, Laiko General Hospital, National and Kapodistrian University of Athens, Athens, Greece.

出版信息

Ann Vasc Surg. 2020 Oct;68:338-343. doi: 10.1016/j.avsg.2020.04.015. Epub 2020 May 1.

DOI:10.1016/j.avsg.2020.04.015

PMID:32360698

Abstract

BACKGROUND

Krüppel-like factor 4 (KLF4) is known to preserve vascular homeostasis. In the present study, we sought to correlate serum KLF4 levels with arterial aneurysm size and their clinical presentation. We also explored the association between serum KLF4 levels and the severity of extracranial carotid and peripheral arterial disease.

METHODS

Patients undergoing surgery for various forms of atheromatosis (ATH group) or for arterial aneurysm repair (AA group) were eligible for inclusion. KLF4 levels were measured via enzyme-linked immunosorbent assay.

RESULTS

Patients in the atheromatic and aneurysmal groups had significantly higher serum KLF4 levels compared with controls. Patients with permanent end-organ damage (ATH3) had higher serum KLF4 (6.96 ± 0.75 pg/mL) compared with patients with asymptomatic internal carotid stenosis >70% or claudication (ATH1) (2.76 ± 0.68 pg/mL; mean difference [MD], -4.20; 95% confidence interval [95% CI], -5.35 to -3.04; P < 0.01) and those with transient ischemic attack or rest pain (ATH2) (4.47 ± 1.08 pg/mL; MD, -2.48; 95% CI, -3.76 to -1.21). Furthermore, patients with an asymptomatic aneurysm of a diameter 250-300% of that of the normal artery (AA1, 5.01 ± 1.08 pg/mL) had considerably lower serum KLF4 compared with those suffering from either a symptomatic aneurysm or an asymptomatic aneurysm of a diameter >350% of that of normal artery (AA3, 6.63 ± 1.92 pg/mL; MD, -2.61; 95% CI, -5.04 to -0.18; P < 0.01).

CONCLUSIONS

Serum KLF4 levels are significantly increased in patients with end-organ damage related to atheromatosis as well as those with extensive aneurysmal disease.

摘要

背景

已知Krüppel样因子4（KLF4）可维持血管稳态。在本研究中，我们试图将血清KLF4水平与动脉瘤大小及其临床表现相关联。我们还探讨了血清KLF4水平与颅外颈动脉和外周动脉疾病严重程度之间的关联。

方法

接受各种形式动脉粥样硬化手术的患者（动脉粥样硬化组）或接受动脉瘤修复手术的患者（动脉瘤组）符合纳入标准。通过酶联免疫吸附测定法测量KLF4水平。

结果

与对照组相比，动脉粥样硬化组和动脉瘤组患者的血清KLF4水平显著更高。与无症状性颈内动脉狭窄>70%或间歇性跛行患者（动脉粥样硬化1组）（2.76±0.68 pg/mL；平均差值[MD]，-4.20；95%置信区间[95%CI]，-5.35至-3.04；P<0.01）以及短暂性脑缺血发作或静息痛患者（动脉粥样硬化2组）（4.47±1.08 pg/mL；MD，-2.48；95%CI，-3.76至-1.21）相比，有永久性终末器官损伤的患者（动脉粥样硬化3组）血清KLF4水平更高（6.96±0.75 pg/mL）。此外，与患有有症状动脉瘤或直径>正常动脉直径350%的无症状动脉瘤的患者（动脉瘤3组）（6.63±1.92 pg/mL；MD，-2.61；95%CI，-5.04至-0.18；P<0.01）相比，直径为正常动脉直径250%至300%的无症状动脉瘤患者（动脉瘤1组）血清KLF4水平显著更低（5.01±1.08 pg/mL）。