Mousavi-Mirzaei Seyed Mohammad, Khorasani Emad Yeganeh, Amirabadizadeh Alireza, Nakhaee Samaneh, Baharshahi Amin, Rajabpour-Sanati Ali, Talebi Abolfazl, Lamarine Roland J, Mehrpour Mahsa, Mehrpour Omid
Medical Toxicology and Drug Abuse Research Center (MTDRC), Birjand University of Medical Sciences, Birjand, Iran.
Student research committee, Birjand University of Medical Sciences, Birjand, Iran.
J Trace Elem Med Biol. 2020 Sep;61:126532. doi: 10.1016/j.jtemb.2020.126532. Epub 2020 Apr 18.
Stroke is the main cause of mortality and long-term disability in the general population. With the increased application of metals in industries and human environment, lead has become a health hazard. In this study, we aimed to evaluate the relationship between the blood concentration of lead and the incidence of acute stroke.
We performed this study during 2016-17 at Vali-e-Asr Hospital in Birjand, Iran, among 80 ischemic stroke patients visiting the hospital and 80 healthy gender- and age-matched controls. Blood lead concentration (BLC) was measured using graphite furnace atomic absorption spectrometry.
BLC medians in the case and control groups were 20.65 [5.37-34.87] μg/dL and 2.65 [1.75-13.85] μg/dL, respectively (p < 0.05). The case group had significantly lower mean levels of HDL and phosphors, whereas the mean levels of white blood cells and uric acid were higher in this group. After adjusting for lipid profile and fasting blood sugar, multiple logistic regression indicated that the serum levels of uric acid and BLC were significant for predicting ischemic stroke. It is estimated that the odds ratio of ischemic stroke increases by 1.04 per 1 μg/dl increase in BLC.
This study showed that lead can be a risk factor for ischemic stroke. Since it does not have any beneficial effects on the health of individuals, screening serum concentrations of lead can be considered as a preventive strategy for those at risk of stroke.
中风是普通人群死亡和长期残疾的主要原因。随着金属在工业和人类环境中的应用增加，铅已成为一种健康危害。在本研究中，我们旨在评估血铅浓度与急性中风发病率之间的关系。
我们于2016 - 2017年在伊朗比尔詹德的瓦利 - 阿斯尔医院对80名前来就诊的缺血性中风患者和80名年龄及性别匹配的健康对照者进行了研究。使用石墨炉原子吸收光谱法测量血铅浓度（BLC）。
病例组和对照组的BLC中位数分别为20.65[5.37 - 34.87]μg/dL和2.65[1.75 - 13.85]μg/dL（p < 0.05）。病例组的高密度脂蛋白和磷的平均水平显著较低，而该组白细胞和尿酸的平均水平较高。在调整血脂谱和空腹血糖后，多因素逻辑回归表明尿酸和BLC水平对预测缺血性中风具有显著意义。据估计，BLC每增加1μg/dl，缺血性中风的比值比增加1.04。
本研究表明铅可能是缺血性中风的一个危险因素。由于它对个体健康没有任何有益影响，因此可以考虑将筛查血清铅浓度作为中风高危人群的预防策略。
