Fatima Tooba, Iftikhar Sadaf, Qureshi Irshad Hussain
Department of Medicine, King Edward Medical University / Mayo Hospital, Lahore, Pakistan.
Department of Neurology, King Edward Medical University / Mayo Hospital, Lahore, Pakistan.
J Coll Physicians Surg Pak. 2020 Aug;30(8):853-856. doi: 10.29271/jcpsp.2020.08.853.
To find the association between hyperuricemia and ischemic stroke.
Case-control study.
Departments of Medicine and Neurology, Mayo Hospital, Lahore, from October 2015 to September 2016.
A total of 100 patients were recruited in the study. Fifty cases were of acute ischemic stroke and fifty were age- and gender-matched healthy controls. Serum uric acid level was estimted by photometry method at the time of admission. Hyperuricemia was defined as the serum uric acid level of more than 6 mg/dl.
Mean serum uric acid levels in cases and controls were 5.996 ±1.99 mg/dl and 5.042 ±0.91 mg/dl, respectively. Hyperuricemia was present in 23 (46%) patients with ischemic stroke and in 10 (20%) controls. Among ischemic stroke patients, the frequency of hyperuricemia was significantly higher than in controls (p-value =0.006, Odds Ratio (OR) =3.41.) Conclusion: Serum uric acid was found significantly elevated in ischemic stroke patients versus controls with 3.41 times more risk of having hyperuricemia in ischemic stroke patients. Key Words: Hyperuricemia, Ischemic stroke, Serum uric acid (SUA).
探讨高尿酸血症与缺血性卒中之间的关联。
病例对照研究。
拉合尔梅奥医院内科和神经内科，2015年10月至2016年9月。
本研究共纳入100例患者。其中50例为急性缺血性卒中患者，50例为年龄和性别匹配的健康对照。入院时采用光度法测定血清尿酸水平。高尿酸血症定义为血清尿酸水平超过6mg/dl。
病例组和对照组的平均血清尿酸水平分别为5.996±1.99mg/dl和5.042±0.91mg/dl。23例（46%）缺血性卒中患者存在高尿酸血症，10例（20%）对照者存在高尿酸血症。在缺血性卒中患者中，高尿酸血症的发生率显著高于对照组（p值=0.006，比值比（OR）=3.41）。结论：缺血性卒中患者的血清尿酸水平显著高于对照组，缺血性卒中患者发生高尿酸血症的风险是对照组的3.41倍。关键词：高尿酸血症；缺血性卒中；血清尿酸（SUA）
