Section of Investigative Medicine, Imperial College, London, UK.
Institute of Reproductive and Developmental Biology, Imperial College, London, UK.
Clin Endocrinol (Oxf). 2020 Sep;93(3):312-321. doi: 10.1111/cen.14213. Epub 2020 May 19.
There are no current pharmacological therapies to improve sperm quality in men with sub-fertility. Reducing the exposure to lifestyle risk factor (LSF) is currently the only intervention for improving sperm quality in men with sub-fertility. No previous study has investigated what proportion of men with sub-fertility are exposed to adverse lifestyle factors. Furthermore, it is not known to what extent men with sub-fertility are aware of lifestyle factors potentially adversely impacting their fertility.
A cross-sectional anonymous questionnaire-based study on self-reported exposure and awareness of LSF was conducted in 1149 male partners of couples investigated for sub-fertility in a tertiary andrology centre in London, UK.
Seventy per cent of men investigated for sub-fertility had ≥1 LSF, and twenty-nine per cent had ≥2 LSF. Excessive alcohol consumption was the most common LSF (40% respondents). Seventeen per cent of respondents used recreational drugs (RD) regularly, but only 32% of RD users believed RD impair male fertility. Twenty-five per cent of respondents were smokers, which is higher than the UK average (20%). Twenty-seven per cent of respondents had a waist circumference (WC) >36 inches (91 cm), and 4% had WC >40 inches (102 cm). Seventy-nine per cent of respondents wanted further lifestyle education to improve their fertility.
Our data suggest that men with sub-fertility are as follows: (a) exposed to one or more LSF; (b) have incomplete education about how LSF may cause male sub-fertility; (c) want more education about reducing LSF. Further studies are needed to investigate the potential of enhanced education of men about LSF to treat couples with sub-fertility.
目前尚无改善不育男性精子质量的药物治疗方法。减少生活方式风险因素（LSF）的暴露是目前改善不育男性精子质量的唯一干预措施。以前没有研究调查过有多少不育男性接触过不良生活方式因素。此外，尚不清楚不育男性对可能影响其生育能力的生活方式因素的认识程度。
在英国伦敦的一家三级男科中心，对 1149 名接受不育症检查的男性伴侣进行了一项横断面匿名基于问卷的研究，以调查他们对 LSF 的自我报告暴露和认识情况。
70%接受不育症检查的男性存在≥1 种 LSF，29%存在≥2 种 LSF。过度饮酒是最常见的 LSF（40%的受访者）。17%的受访者经常使用娱乐性药物（RD），但只有 32%的 RD 用户认为 RD 会损害男性生育能力。25%的受访者吸烟，这高于英国的平均水平（20%）。27%的受访者腰围（WC）>36 英寸（91 厘米），4%的 WC >40 英寸（102 厘米）。79%的受访者希望进一步进行生活方式教育，以提高他们的生育能力。
我们的数据表明，不育男性存在以下情况：（a）接触一种或多种 LSF；（b）对 LSF 如何导致男性不育的了解不完整；（c）希望接受更多关于减少 LSF 的教育。需要进一步研究，以调查增强男性对 LSF 的教育以治疗不育夫妇的潜力。
