头孢菌素酯的异构化：对提高头孢菌素口服生物利用度的前药酯方法的影响。 - Suppr

Suppr

超能文献

Isomerization of cephalosporin esters: implications for the prodrug ester approach to enhancing the oral bioavailabilities of cephalosporins.

作者信息

Saab A N, Dittert L W, Hussain A A

机构信息

College of Pharmacy, University of Kentucky, Lexington 40536-0082.

出版信息

J Pharm Sci. 1988 Oct;77(10):906-7. doi: 10.1002/jps.2600771020.

DOI:10.1002/jps.2600771020

PMID:3236237

Abstract

摘要

相似文献

Isomerization of cephalosporin esters: implications for the prodrug ester approach to enhancing the oral bioavailabilities of cephalosporins.头孢菌素酯的异构化：对提高头孢菌素口服生物利用度的前药酯方法的影响。

J Pharm Sci. 1988 Oct;77(10):906-7. doi: 10.1002/jps.2600771020.

Pharmacokinetics and bioavailability of oral cephalosporins, KR-984055 and its prodrugs, KR-999001 and KR-999002, in the rat.

Arch Pharm Res. 2003 Jan;26(1):83-8. doi: 10.1007/BF03179937.

Studies on orally active cephalosporin esters. V. A prodrug approach for oral delivery of 3-thiazoliomethyl cephalosporin.

Chem Pharm Bull (Tokyo). 1990 Jul;38(7):1906-10. doi: 10.1248/cpb.38.1906.

Stability of cephalosporin prodrug esters in human intestinal juice: implications for oral bioavailability.头孢菌素前药酯在人肠液中的稳定性：对口服生物利用度的影响

Antimicrob Agents Chemother. 1998 Oct;42(10):2602-6. doi: 10.1128/AAC.42.10.2602.

Studies on orally active cephalosporin esters. II. Chemical stability of pivaloyloxymethyl esters in phosphate buffer solution.

Chem Pharm Bull (Tokyo). 1989 Sep;37(9):2369-74. doi: 10.1248/cpb.37.2369.

Synthesis and biological activity of novel 3-(2-propenyl)-cephalosporins. II. Preparation of prodrugs.新型3-（2-丙烯基）-头孢菌素的合成与生物活性。II. 前药的制备。

J Antibiot (Tokyo). 1991 Oct;44(10):1083-7. doi: 10.7164/antibiotics.44.1083.

KY-109, a new bifunctional prodrug of cephalosporin. II. Mechanism of oral absorption.

Chem Pharm Bull (Tokyo). 1988 Jun;36(6):2128-34. doi: 10.1248/cpb.36.2128.

Determination of cefcanel in plasma and urine by high-performance liquid chromatography using coupled columns, after administration of the new cephalosporin prodrug cefcanel daloxate hydrochloride.新型头孢菌素前药盐酸头孢卡奈达酯给药后，采用联用柱高效液相色谱法测定血浆和尿液中的头孢卡奈。

J Chromatogr. 1992 Jul 1;578(1):71-6. doi: 10.1016/0378-4347(92)80226-g.

In vitro and in vivo evaluations of the metabolism, pharmacokinetics, and bioavailability of ester prodrugs of L-767,679, a potent fibrinogen receptor antagonist: an approach for the selection of a prodrug candidate.强效纤维蛋白原受体拮抗剂L-767,679酯前药的代谢、药代动力学及生物利用度的体外和体内评价：一种前药候选物的筛选方法

Drug Metab Dispos. 1997 Aug;25(8):978-84.

Oral prodrug enters cephalosporin market.

Am J Health Syst Pharm. 2001 Nov 1;58(21):2018. doi: 10.1093/ajhp/58.21.2018.

引用本文的文献

Effect of C-2 substitution on the stability of non-traditional cephalosporins in mouse plasma.C-2 取代对非传统头孢菌素在小鼠血浆中稳定性的影响。

J Antibiot (Tokyo). 2019 Jun;72(6):469-475. doi: 10.1038/s41429-019-0167-y. Epub 2019 Mar 22.

Stability of cephalosporin prodrug esters in human intestinal juice: implications for oral bioavailability.头孢菌素前药酯在人肠液中的稳定性：对口服生物利用度的影响

Antimicrob Agents Chemother. 1998 Oct;42(10):2602-6. doi: 10.1128/AAC.42.10.2602.

Prodrugs for the improvement of drug absorption via different routes of administration.用于通过不同给药途径改善药物吸收的前体药物。

Eur J Drug Metab Pharmacokinet. 1990 Apr-Jun;15(2):143-53. doi: 10.1007/BF03190197.

文献AI研究员

20分钟写一篇综述，助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型，支持多种主流文档格式。

立即体验