Value of Pretreatment F-fluorodeoxyglucose Positron Emission Tomography in Patients With Localized Pancreatic Cancer Treated With Neoadjuvant Therapy.

F-fluorodeoxyglucose positron emission tomography/computed tomography (PET/CT) imaging is not routine in patients with localized pancreatic cancer (PC). We evaluated the prognostic value of PET/CT in patients who received neoadjuvant therapy. Patients with localized PC underwent pretreatment PET/CT with or without posttreatment (preop) PET/CT. Maximum standardized uptake values (SUV) were classified as high or low based on a cut point of 7.5 at diagnosis (SUV) and 3.5 after neoadjuvant therapy (preoperative; SUV). Preop carbohydrate antigen 19-9 (CA19-9) was classified as normal ( ≤ 35 U/mL) or elevated. Pretreatment PET/CT imaging was performed on 201 consecutive patients; SUV was high in 98 (49%) and low in 103 (51%). Preop PET/CT was available in 104 (52%) of the 201 patients; SUV was high in 60 (58%) and low in 44 (42%). Following neoadjuvant therapy, preop CA19-9 was normal in 90 (45%) patients and elevated in 111 (55%). Median overall survival (OS) of all patients was 27 months; 33 months for the 103 patients with a low SUV and 22 months for the 98 patients with a high SUV ( = 0.03). Median OS for patients with low SUV/normal preop CA19-9, high SUV/normal preop CA19-9, low SUV/elevated preop CA19-9, and high SUV/elevated preop CA19-9 were 66, 34, 23, and 17 months, respectively ( < 0.0001). OS was 44 months for the 148 (74%) patients who completed all intended neoadjuvant therapy and surgery and 13 months for the 53 (26%) who did not undergo surgery ( < 0.001). Pretreatment PET/CT avidity and preop CA19-9 are clinically significant prognostic markers in patients with PC.