Mooser V, Waeber B, Nussberger J, Brunner H R
Division of Hypertension, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland.
J Hum Hypertens. 1988 Dec;2(4):257-60.
This study was undertaken to compare the antihypertensive effect of diltiazem administered once or twice daily. After a two week wash-out period, eight hypertensive patients were treated for two consecutive four week phases with 180 mg once daily or 90 mg twice daily of a sustained-release formulation of diltiazem. The sequence of the treatments was randomised and the trial carried out in a double-blind fashion. Ambulatory daytime BP profiles were obtained using a portable BP recorder (Remler M2000). The average of all BP readings taken during the monitoring period was 159/104 +/- 21/10 mgHg (mean +/- SD) at the end of the wash-out period and 145/90 +/- 20/12 and 148/95 +/- 21/11 mmHg under treatment with diltiazem 180 mg once daily and 90 mg twice daily, respectively. These data indicate that 180 mg of a slow-release formulation of diltiazem are as effective in lowering the BP of hypertensive patients when administered daily in a single dose as when divided into two doses.
本研究旨在比较每日服用一次或两次地尔硫䓬的降压效果。经过两周的洗脱期后，8名高血压患者连续接受两个为期四周的治疗阶段，分别给予每日一次180毫克或每日两次90毫克的地尔硫䓬缓释制剂。治疗顺序随机安排，试验采用双盲方式进行。使用便携式血压记录仪（Remler M2000）获取日间动态血压曲线。在洗脱期结束时，监测期间所有血压读数的平均值为159/104±21/10 mmHg（均值±标准差），在分别接受每日一次180毫克和每日两次90毫克地尔硫䓬治疗时，血压分别为145/90±20/12 mmHg和148/95±21/11 mmHg。这些数据表明，180毫克地尔硫䓬缓释制剂每日单次给药与分两次给药在降低高血压患者血压方面效果相同。
