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亚洲的猫传染性真菌病。

Feline sporotrichosis in Asia.

机构信息

Vetderm Animal Skin and Ear Specialist Clinic, 9-1 JLN 23/70A, Plaza Crystalville 1, Desa Sri Hartamas, 50480, Kuala Lumpur, Malaysia.

Department of Veterinary Dermatology, Nihon University College of Bioresource Sciences, 1866 Kameino, Fujisawa, Kanagawa, 252-0880, Japan.

出版信息

Braz J Microbiol. 2021 Mar;52(1):125-134. doi: 10.1007/s42770-020-00274-5. Epub 2020 May 3.

Abstract

Sporothrix schenckii sensu lato is currently recognized as a species complex with only Sporothrix brasiliensis, Sporothrix schenckii sensu stricto, Sporothrix globosa and Sporothrix pallida identified to cause disease in the cat. Feline sporotrichosis in Asia is mainly reported from Malaysia where a single clonal strain of clinical clade D, Sporothrix schenckii sensu stricto manifesting low susceptibility to major antifungal classes, has been identified as the agent of the disease. Sporothrix globosa has been identified to cause disease from a single cat in Japan while the specific species of agent has not been identified yet for the disease in Thailand. Despite efforts to elucidate and describe the pathogenicity of the agent and the disease it causes, the paucity of data highlights the need for further molecular epidemiological studies to characterize this fungus and the disease it causes in Asia. Its prognosis remains guarded to poor due to issues pertaining to cost, protracted treatment course, zoonotic potential and low susceptibility of some strains to antifungals.

摘要

申克孢子丝菌同义种目前被认为是一个种复合体,仅鉴定出巴西申克孢子丝菌、申克孢子丝菌狭义种、球形孢子丝菌和苍白密丝孢可引起猫患病。亚洲的猫孢子丝菌病主要见于马来西亚,在那里已鉴定出临床分支 D 的单一克隆株,即申克孢子丝菌狭义种,对主要抗真菌类药物的敏感性较低,被认为是该病的病原体。已从日本的一只猫中鉴定出球形孢子丝菌可引起疾病,而该病在泰国的病原体的具体种尚未确定。尽管已经努力阐明和描述病原体及其引起的疾病的致病性,但数据的缺乏突出表明需要进一步进行分子流行病学研究,以对亚洲的这种真菌及其引起的疾病进行特征描述。由于涉及成本、治疗过程漫长、人畜共患潜力和一些菌株对抗真菌药物的低敏感性等问题,其预后仍然较差。

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