Lee Duk-Hee, Jacobs David R, Lind Lars, Lind P Monica
Department of Preventive Medicine, School of Medicine, Kyungpook National University, Daegu, 41944, Korea.
Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, Minnesota, 55454, USA.
Bioessays. 2020 Jun;42(6):e1900237. doi: 10.1002/bies.201900237. Epub 2020 May 4.
Intentional weight loss can increase health risk in the long-term, despite short-term benefits, because human adipose tissue is widely contaminated with various lipophilic environmental contaminants, especially persistent organic pollutants (POPs). Recently, chronic exposure to low POPs has emerged as a new risk factor for common metabolic diseases and cardiovascular diseases. The amount of POPs released from adipocytes to the circulation increases during weight loss, thereby increasing POPs exposure of other critical organs. Possible harmful effects due to release of POPs during weight loss are opposite to those usually expected from losing weight. It is speculated that this tradeoff can explain recent puzzling findings on intensive weight loss. The presence of POPs in adipose tissue adds a challenge to weight management and an optimal strategy of weight management needs to consider both fat mass and dynamics of POPs.
尽管有意减肥在短期内有好处，但从长远来看会增加健康风险，因为人体脂肪组织广泛受到各种亲脂性环境污染物的污染，尤其是持久性有机污染物（POPs）。最近，长期低剂量接触持久性有机污染物已成为常见代谢疾病和心血管疾病的一个新风险因素。减肥期间，脂肪细胞释放到循环系统中的持久性有机污染物数量会增加，从而增加其他重要器官接触持久性有机污染物的机会。减肥过程中持久性有机污染物释放可能产生的有害影响与通常因体重减轻而预期的影响相反。据推测，这种权衡可以解释最近关于剧烈减肥的一些令人困惑的发现。脂肪组织中持久性有机污染物的存在给体重管理带来了挑战，而最佳的体重管理策略需要同时考虑脂肪量和持久性有机污染物的动态变化。
