Field B, Kerr C
Department of Paediatrics, University of Sydney, New South Wales, Australia.
J Med Genet. 1988 Dec;25(12):819-26. doi: 10.1136/jmg.25.12.819.
In view of the persistent claim of Australian Vietnam veterans that their health and that of their children were adversely affected, aspects of reproductive behaviour and the distribution of disease and disability in family units were investigated in a sample of Tasmanian veterans and another group chosen for comparison of selected characteristics. One third of veterans reported serious health problems and their reproductive behaviour differed with more marital breakdowns, increased use of reproductive alternatives, and more complications of pregnancy. Patterns of malformation and disease among veterans' children involved predominantly the central nervous, skeletal, and cardiovascular systems. A similar pattern was detected on review of the three other major investigations on veterans' offspring in the USA and Australia. Although plausible mechanisms remain unknown, the evidence from all available studies supports a causal contribution to defects in veterans' children from a paternally mediated genetic effect.
鉴于澳大利亚越战退伍军人一直声称他们及其子女的健康受到了不利影响，我们对塔斯马尼亚退伍军人样本以及另一组为比较选定特征而挑选的人群的生殖行为、疾病分布和家庭单位中的残疾情况进行了调查。三分之一的退伍军人报告有严重健康问题，他们的生殖行为有所不同，婚姻破裂更多，更多地使用生殖替代方法，且怀孕并发症更多。退伍军人子女的畸形和疾病模式主要涉及中枢神经、骨骼和心血管系统。在美国和澳大利亚对退伍军人后代进行的其他三项主要调查中也发现了类似模式。尽管合理的机制仍然不明，但所有现有研究的证据都支持父系介导的遗传效应会导致退伍军人子女出现缺陷。
