Department of Otolaryngology-Head and Neck Surgery, University of Utah, Salt Lake City, Utah, U.S.A.
Laryngoscope. 2021 Feb;131(2):E635-E641. doi: 10.1002/lary.28711. Epub 2020 May 4.
OBJECTIVES/HYPOTHESIS: To review the demographics, treatment, and survival of pediatric melanoma of the head and neck and to determine if melanoma of the head and neck has worse survival than melanoma of other body sites.
Retrospective database review.
Pediatric patients from 0 to 21 years in the Surveillance, Epidemiology, and End Results 18 registries database were included from 1975 to 2016 based on a diagnosis of melanoma of the skin using the primary site International Classification of Diseases for Oncology, Third Edition codes from C44.0-C44.9.skin of lip, C44.1-eyelid, C44.2-external ear, C44.3-skin other/unspecified parts of face, C44.4-skin of scalp and neck, C44.5-skin of trunk, C44.6-skin of upper limb and shoulder, C44.7-skin of lower limb and hip, C44.8-overlapping lesion of skin, and C44.9-skin, NOS (not otherwise specified).
A total of 4,561 pediatric melanomas of the skin were identified. There were 854 (18.7%) cases of melanoma of the head and neck (MHN) and 3,707 (81.3%) cases of melanoma of the body (MOB). The hazard ratio for MHN versus MOB was 1.6 (95% confidence interval: 1.3-2.1) after accounting for sex, race, and age. Of MHN sites, the hazard ratio for melanoma of the scalp and neck was 2.2 (1.1-4.7). The 2- and 5-year Kaplan-Meier overall survival for MHN were 94.6% and 90.7%, respectively, compared with 96.6% and 94.7%, respectively, for MOB (P < .01).
Survival outcomes of pediatric melanoma are notably related to anatomic site. Children with melanoma of the scalp and neck have the worst survival of all sites. Additionally, children who are older/white/male are at greater risk for worse survival outcomes.
3 Laryngoscope, 131:E635-E641, 2021.
目的/假设：回顾头颈部儿童黑色素瘤的人口统计学、治疗和生存情况，并确定头颈部黑色素瘤的生存是否比其他身体部位的黑色素瘤更差。
回顾性数据库研究。
根据国际肿瘤学疾病分类第三版的主要部位代码 C44.0-C44.9（唇皮肤、C44.1-眼睑、C44.2-外耳、C44.3-面部其他/未指定部位的皮肤、C44.4-头皮和颈部皮肤、C44.5-躯干皮肤、C44.6-上肢和肩部皮肤、C44.7-下肢和臀部皮肤、C44.8-皮肤重叠病变、C44.9-皮肤，NOS（未另作说明），从 1975 年至 2016 年，在监测、流行病学和最终结果 18 个登记处数据库中纳入了 0 至 21 岁的儿科患者，这些患者被诊断为皮肤黑色素瘤。
共确定了 4561 例儿童皮肤黑色素瘤。头颈部黑色素瘤（MHN）有 854 例（18.7%），身体黑色素瘤（MOB）有 3707 例（81.3%）。在考虑性别、种族和年龄后，MHN 与 MOB 的危险比为 1.6（95%置信区间：1.3-2.1）。在 MHN 部位中，头皮和颈部黑色素瘤的危险比为 2.2（1.1-4.7）。MHN 的 2 年和 5 年 Kaplan-Meier 总生存率分别为 94.6%和 90.7%，而 MOB 分别为 96.6%和 94.7%（P<0.01）。
儿童黑色素瘤的生存结果与解剖部位密切相关。头皮和颈部黑色素瘤患儿的生存最差。此外，年龄较大/白人/男性的儿童患更差的生存结果的风险更高。
3 Laryngoscope，131：E635-E641，2021。
