School of Electrical and Computer Engineering, Ben-Gurion University of the Negev, Beer-Sheva, 8410501, Israel; Ilse Katz Institute for Nanoscale Science & Technology, Ben-Gurion University of the Negev, Beer-Sheva 8410501, Israel.
The Shraga Segal Department of Microbiology, Immunology and Genetics, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, 8410501, Israel.
Biosens Bioelectron. 2020 Aug 1;161:112240. doi: 10.1016/j.bios.2020.112240. Epub 2020 Apr 25.
Uncontrolled growth of ovarian cancer cells is the fifth leading cause of female cancer deaths since most ovarian cancer patients are diagnosed at an advanced stage of metastatic disease. Here, we report on the sensor for monitoring the cancer treatment efficiency in real-time. We measure the optical interaction between the evanescent fields of microfiber and ovarian cancer inter-cellular medium at different treatment stages. Spectral absorption signatures are correlated with optical micrographs and western blot tests. We found that the treatment of tumor cells with induces both cells growth arrest and alter the spectral lines in a dose-dependent manner. These observations are mediated by surface roughness out of silica glass material, form an essential step toward the development of early detection of response to cancer therapy.
卵巢癌细胞的不受控制的生长是女性癌症死亡的第五大主要原因，因为大多数卵巢癌患者在转移性疾病的晚期被诊断出来。在这里，我们报告了一种用于实时监测癌症治疗效果的传感器。我们在不同的治疗阶段测量微光纤和卵巢癌细胞间质之间的消逝场的光学相互作用。光谱吸收特征与光学显微镜和western blot 测试相关联。我们发现，用处理肿瘤细胞会导致细胞生长停滞，并以剂量依赖的方式改变谱线。这些观察结果是由二氧化硅玻璃材料的表面粗糙度介导的，为开发癌症治疗反应的早期检测奠定了重要基础。
