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p66shc siRNA-Encapsulated PLGA Nanoparticles Ameliorate Neuropathic Pain Following Spinal Nerve Ligation.

作者信息

Shin Nara, Shin Hyo Jung, Yi Yoonyoung, Beom Jaewon, Lee Wonhyung, Lee Choong-Hyun, Kim Dong Woon

机构信息

Department of Medical Science, Chungnam National University College of Medicine, Daejeon 35015, Korea.

Department of Anatomy, Brain Research Institute, Chungnam National University College of Medicine, Daejeon 35015, Korea.

出版信息

Polymers (Basel). 2020 Apr 29;12(5):1014. doi: 10.3390/polym12051014.

DOI:10.3390/polym12051014
PMID:32365512
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7284875/
Abstract

p66shc, a member of the shc adaptor protein family, has been shown to participate in regulation of mitochondrial homeostasis, apoptosis, and autophagosome formation. The present study was performed to investigate whether p66shc siRNA-encapsulated poly(d,l-lactic--glycolic acid) nanoparticles (p66shc siRNA-PLGA NPs) can attenuate spinal nerve ligation (SNL)-induced neuropathic pain in rats. The SNL-induced pain behavior was decreased in the p66shc siRNA-PLGA NP-treated group compared with the scrambled siRNA-PLGA NP-treated group. In the L5 spinal cord of the p66shc siRNA-PLGA NP-treated group, expression levels of phosphorylated p66shc, cleaved caspase-3, p62, and PINK1, as well as microglial activation, were also decreased. In addition, p66shc knockdown using p66shc siRNA reduced the expression levels of cleaved caspase-3, p62, and PINK1, as well as proinflammatory mediators in the HO-treated HT22 neuronal cells. These results suggest that downregulation of p66shc expression in the spinal cord using p66shc siRNA-PLGA NPs could reduce the SNL-induced neuropathic pain by attenuating the SNL-induced aberrant autophagic, mitophagic, and neuroinflammatory processes in rats.

摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ae71/7284875/f11532c0c1a8/polymers-12-01014-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ae71/7284875/60300af529bc/polymers-12-01014-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ae71/7284875/a5ab5e9bd241/polymers-12-01014-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ae71/7284875/fadafa7318e3/polymers-12-01014-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ae71/7284875/960df1df8599/polymers-12-01014-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ae71/7284875/00ef7b83311d/polymers-12-01014-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ae71/7284875/f11532c0c1a8/polymers-12-01014-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ae71/7284875/60300af529bc/polymers-12-01014-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ae71/7284875/a5ab5e9bd241/polymers-12-01014-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ae71/7284875/fadafa7318e3/polymers-12-01014-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ae71/7284875/960df1df8599/polymers-12-01014-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ae71/7284875/00ef7b83311d/polymers-12-01014-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ae71/7284875/f11532c0c1a8/polymers-12-01014-g006.jpg

相似文献

[1]
p66shc siRNA-Encapsulated PLGA Nanoparticles Ameliorate Neuropathic Pain Following Spinal Nerve Ligation.

Polymers (Basel). 2020-4-29

[2]
CX3CR1-Targeted PLGA Nanoparticles Reduce Microglia Activation and Pain Behavior in Rats with Spinal Nerve Ligation.

Int J Mol Sci. 2020-5-14

[3]
siRNA-Encapsulated Poly (Lactic--Glycolic Acid) Nanoparticles Diminish Neuropathic Pain by Inhibiting Microglial Activation.

Int J Mol Sci. 2021-5-26

[4]
p38 siRNA-encapsulated PLGA nanoparticles alleviate neuropathic pain behavior in rats by inhibiting microglia activation.

Nanomedicine (Lond). 2018-7

[5]
Intrathecal injection of phosphodiesterase 4B-specific siRNA attenuates neuropathic pain in rats with L5 spinal nerve ligation.

Mol Med Rep. 2016-2

[6]
Foxp3 plasmid-encapsulated PLGA nanoparticles attenuate pain behavior in rats with spinal nerve ligation.

Nanomedicine. 2019-3-8

[7]
Nefopam downregulates autophagy and c-Jun N-terminal kinase activity in the regulation of neuropathic pain development following spinal nerve ligation.

BMC Anesthesiol. 2018-7-27

[8]
Upregulated TLR3 Promotes Neuropathic Pain by Regulating Autophagy in Rat With L5 Spinal Nerve Ligation Model.

Neurochem Res. 2017-2

[9]
PINK1 mediates spinal cord mitophagy in neuropathic pain.

J Pain Res. 2019-5-28

[10]
Contribution of the spinal cord BDNF to the development of neuropathic pain by activation of the NR2B-containing NMDA receptors in rats with spinal nerve ligation.

Exp Neurol. 2010-1-14

引用本文的文献

[1]
The Role of p66Shc in Cancer: Molecular Mechanisms and Therapeutic Implications.

J Cell Mol Med. 2025-7

[2]
RNA Interference Unleashed: Current Perspective of Small Interfering RNA (siRNA) Therapeutics in the Treatment of Neuropathic Pain.

ACS Pharmacol Transl Sci. 2024-9-23

[3]
Evodiamine ameliorates intervertebral disc degeneration through the Nrf2 and MAPK pathways.

Cytotechnology. 2024-4

[4]
Rejuvenating aged microglia by p16-siRNA-loaded nanoparticles increases amyloid-β clearance in animal models of Alzheimer's disease.

Mol Neurodegener. 2024-3-16

[5]
Epigallocatechin Gallate Potentiates the Anticancer Effect of -siRNA-Loaded Polymeric Nanoparticles on Hepatocellular Carcinoma Cells.

Nanomaterials (Basel). 2023-12-23

[6]
The etiological roles of miRNAs, lncRNAs, and circRNAs in neuropathic pain: A narrative review.

J Clin Lab Anal. 2022-8

[7]
Perampanel Reduces Brain Damage via Induction of M2 Microglia in a Neonatal Rat Stroke Model.

Int J Nanomedicine. 2022

[8]
Mitochondrial Dysfunction in Oxidative Stress-Mediated Intervertebral Disc Degeneration.

Orthop Surg. 2022-8

[9]
Non-Ionic Surfactants for Stabilization of Polymeric Nanoparticles for Biomedical Uses.

Materials (Basel). 2021-6-10

本文引用的文献

[1]
p47phox siRNA-Loaded PLGA Nanoparticles Suppress ROS/Oxidative Stress-Induced Chondrocyte Damage in Osteoarthritis.

Polymers (Basel). 2020-2-13

[2]
Manganese Oxide Nanozymes Ameliorate Mechanical Allodynia in a Rat Model of Partial Sciatic Nerve-Transection Induced Neuropathic Pain.

Int J Nanomedicine. 2019-12-27

[3]
Downregulation of p66Shc can reduce oxidative stress and apoptosis in oxidative stress model of marginal cells of stria vascularis in Sprague Dawley rats.

Drug Des Devel Ther. 2019-9-10

[4]
Evans Blue Reduces Neuropathic Pain Behavior by Inhibiting Spinal ATP Release.

Int J Mol Sci. 2019-9-9

[5]
Dysregulation of p53 and Parkin Induce Mitochondrial Dysfunction and Leads to the Diabetic Neuropathic Pain.

Neuroscience. 2019-8-1

[6]
PINK1 mediates spinal cord mitophagy in neuropathic pain.

J Pain Res. 2019-5-28

[7]
Foxp3 plasmid-encapsulated PLGA nanoparticles attenuate pain behavior in rats with spinal nerve ligation.

Nanomedicine. 2019-3-8

[8]
Metformin relieves neuropathic pain after spinal nerve ligation via autophagy flux stimulation.

J Cell Mol Med. 2018-11-19

[9]
p38 siRNA-encapsulated PLGA nanoparticles alleviate neuropathic pain behavior in rats by inhibiting microglia activation.

Nanomedicine (Lond). 2018-7

[10]
Etiology and Pharmacology of Neuropathic Pain.

Pharmacol Rev. 2018-4

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